Melinda Wuest

TL;DR: In situ click chemistry is used to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity, significantly higher than that of widely used selective cyclooxygenase-2 inhibitors.

TL;DR: An automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical models of prostate cancer confirmed high PSMA-mediated tumor uptake combined with superior clearance parameters and points to a two-step molecular trapping mechanism based on PSMA binding and subsequent internalization leading to retention of radioactivity in PSMA+ LNCaP tumors.

TL;DR: Copper-free strain-promoted click chemistry between (18)F-labeled aza-dibenzocyclooctyne [(18]F]FB-DBCO and various azides showed promising radiopharmacological profil with fast blood clearance as assessed with dynamic small animal PET studies.

TL;DR: Loss of ENT1 activity significantly affected 18F-FLT biodistribution in mice and 18F -FLT uptake in xenograft tumors, suggesting that nucleoside transporters are important mediators of 18F+/− uptake in normal and transformed cells.

TL;DR: 6-deoxy-6-fluoro-d-fructose had a 10-fold higher potency than fructose to inhibit 6-[(18)F]FDF uptake into EMT-6 cells, respectively, and may represent a novel radiotracer for PET imaging of GLUT5 and ketohexokinase-expressing tumors.