M
Melissa J. Reed
Researcher at University of Texas MD Anderson Cancer Center
Publications - 4
Citations - 281
Melissa J. Reed is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: 7,12-Dimethylbenz[a]anthracene & Isopimpinellin. The author has an hindex of 4, co-authored 4 publications receiving 265 citations.
Papers
More filters
Journal ArticleDOI
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Heather E. Kleiner,Suryanarayana V. Vulimiri,Melissa J. Reed,and Ann Uberecken,John DiGiovanni +4 more
TL;DR: The role of P450 1a1 and 1b1 in the metabolic activation of DMBA in mouse epidermis is demonstrated and provides a mechanistic explanation for the differential effects of naturally occurring furanocoumarins (and 7,8-BF) on polycyclic aromatic hydrocarbon skin carcinogenesis.
Journal ArticleDOI
Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis.
Heather E. Kleiner,Suryanarayana V. Vulimiri,William B. Hatten,Melissa J. Reed,Daniel W. Nebert,Colin R. Jefcoate,John DiGiovanni +6 more
TL;DR: Results support a role for both P4501A1 and P 4501B1 in the bioactivation of DMBA; P45 01A2, P4502B1, and possibly P4500A1 inThe bioactivation and a preference for the formation of syn-DMBA-diol epoxide-to-anti-derived adducts in mouse epidermis.
Journal ArticleDOI
Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
TL;DR: Results demonstrate that NOCs, which are present in citrus fruits and other components of the human diet, are capable of inhibiting carcinogen metabolizing enzymes and blocking bioactivation of both B[a]P and DMBA in MCF-7 cells.
Journal ArticleDOI
Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Heather E. Kleiner,Suryanarayana V. Vulimiri,Matthew F. Starost,Melissa J. Reed,John DiGiovanni +4 more
TL;DR: Data indicate that isopimpinellin (and imperatorin) have chemopreventive effects when administered orally on skin tumor initiation by DMBA, and several parameters of systemic toxicity were evaluated following oral dosing.