Melody Morris

TL;DR: It is shown that low-dose TORC1 inhibitor therapy in elderly humans decreased the incidence of all infections, improved influenza vaccination responses, and up-regulated antiviral immunity, as well as an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination in this treatment group.

TL;DR: In this article, a review of recent advances in applying logic-based modeling to mammalian cell biology can be found, along with case studies that demonstrate the utility of such models for studying the relationship between environmental inputs and phenotypic or signaling state outputs of complex signaling networks.

TL;DR: In this article, the authors propose a formalism that can take advantage of complex and dynamic networks to build models of cellular signaling in both physiological and diseased situations, using context-specific medium/high throughput proteomic data.

TL;DR: This work converts a prior knowledge network (obtained from literature or interactome databases) into a computable model that describes graded values of protein activation across multiple pathways, and generates a Computable model yielding successful prediction of new test data and offering biological insight into complex datasets that are difficult to fully analyze by intuition alone.

TL;DR: In this paper, the authors combine network analysis and functional experimentation by using a hybrid approach in which graphs are converted into simple mathematical models that can be trained against biochemical data, which can be used to predict the responses of cell signaling proteins to specific ligands or drugs.