Pathology and genetics of tumours of the urinary system and male genital organs

Renal-cell carcinoma.

https://www.amjmed.com/article/S0149-2918(05)80001-3/pdf

Prognostic effect of weight loss prior tochemotherapy in cancer patients

Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials.

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines

Six patients with metastatic mixed germ-cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to have mature teratoma with absence of malignant histologies. The growth in two patients can be attributed to tense and expansile cysts; the remaining four had firm masses. All patients remain free of disease without further therapy at 5, 13, 14, 25, 66, and 108 months. Early recognition of this previously unreported and unusual clinical circumstance of a benign teratoma to grow after chemotherapy will allow for surgical salvage.

The growing teratoma syndrome

Forty-two cases of sarcomatoid renal cell carcinoma were reviewed clinicopathologically. Twenty-four patients were men, and 18 women; average age was 56.2 years (range, 30-81 years). Eight, 9, 13, and 12 cases were Stages I, II, III, and IV, respectively. Three morphologic patterns of sarcomatoid components were identified: malignant fibrous histiocytomatous (26 cases), fibrosarcomatous (6 cases), and unclassified sarcomatoid (10 cases). Mitotic count, degree of pleomorphism, cellularity, and amount of tumor matrix in the sarcomatoid areas, and similar morphologic parameters in the carcinomatous component all failed to correlate with prognosis, as did tumor size and renal vein involvement by tumor. Clinicopathologic stage was a most significant prognostic factor, with a survival of 49.7 months for Stage I and 6.8 months for combined Stages II, III, and IV. Tumor necrosis in the sarcomatoid area and proportion of sarcomatoid components were also poor prognostic factors. When these factors were compared to the stage, necrosis was an independent variable, however, proportion of sarcomatoid components was a poor prognostic indicator only for Stages I and II.

Sarcomatoid renal cell carcinoma: clinicopathologic. A study of 42 cases.

Metastases from testicular carcinoma Study of 78 autopsied cases

Combination chemotherapy in germinal cell tumors.

Bleomycin sulfate pulmonary toxicity was encountered in nine of 101 patients receiving high-dose therapy for widespread testicular cancer. The pulmonary presentation was separable into two categories: (1) an early or minimal form with dyspnea on exertion, minimal roentgenographic findings, and normal arterial partial pressure of oxygen at rest and (2) a severe form, with prominent roentgenographic findings and hypoxemia at rest. All five patients with the severe form died, while the remaining four patients with the minimal presentation recovered. Prior thoracic radiotherapy appeared to predispose to bleomycin pulmonary toxicity, as this complication developed in five of 12 patients receiving prior chest radiotherapy vs four of 89 not receiving radiotherapy (P (JAMA235:1117-1120, 1976)

https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=jama&articleId=344354&pdfFileName=jama_235_11_026.pdf

Melvin L. Samuels

Papers

The growing teratoma syndrome

Sarcomatoid renal cell carcinoma: clinicopathologic. A study of 42 cases.

Metastases from testicular carcinoma Study of 78 autopsied cases

Combination chemotherapy in germinal cell tumors.

Large-Dose Bleomycin Therapy and Pulmonary Toxicity: A Possible Role of Prior Radiotherapy