抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

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Using Multivariate Statistics

We review evidence for partially segregated networks of brain areas that carry out different attentional functions. One system, which includes parts of the intraparietal cortex and superior frontal cortex, is involved in preparing and applying goal-directed (top-down) selection for stimuli and responses. This system is also modulated by the detection of stimuli. The other system, which includes the temporoparietal cortex and inferior frontal cortex, and is largely lateralized to the right hemisphere, is not involved in top-down selection. Instead, this system is specialized for the detection of behaviourally relevant stimuli, particularly when they are salient or unexpected. This ventral frontoparietal network works as a 'circuit breaker' for the dorsal system, directing attention to salient events. Both attentional systems interact during normal vision, and both are disrupted in unilateral spatial neglect.

Control of goal-directed and stimulus-driven attention in the brain

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Publisher Summary This chapter focuses on the modern notion of short-term memory, called working memory. Working memory refers to the temporary maintenance of information that was just experienced or just retrieved from long-term memory but no longer exists in the external environment. These internal representations are short-lived, but can be maintained for longer periods of time through active rehearsal strategies, and can be subjected to various operations that manipulate the information in such a way that makes it useful for goal-directed behavior. Working memory is a system that is critically important in cognition and seems necessary in the course of performing many other cognitive functions, such as reasoning, language comprehension, planning, and spatial processing. This chapter demonstrates the functional importance of dopamine to working memory function in several ways. Elucidation of the cognitive and neural mechanisms underlying human working memory is an important focus of cognitive neuroscience and neurology for much of the past decade. One conclusion that arises from research is that working memory, a faculty that enables temporary storage and manipulation of information in the service of behavioral goals, can be viewed as neither a unitary, nor a dedicated system. Data from numerous neuropsychological and neurophysiological studies in animals and humans demonstrates that a network of brain regions, including the prefrontal cortex, is critical for the active maintenance of internal representations.

Chapter 11 Working memory

Separate visual pathways for perception and action.

Prologue 1. Introduction: vision from a biological point of view 2. Visual processing in the primate visual cortex 3. 'Cortical blindness' 4. Disorders of spatial perception and the visual control of action 5. Disorders of visual recognition 6. Dissociations between perception and action in normal subjects 7. Attention, consciousness, and the coordination of behaviour 8. Epilogue: twelve years on

/pdf/the-visual-brain-in-action-31pkfa7sp0.pdf

The visual brain in action

"Analysis of Visual Behavior" encompasses both theoretical and experimental research. It deals with the visual mechanisms of diverse vertebrate species from salamanders and toads to primates and humans and presents a stimulating interaction of the disciplines of anatomy, physiology, and behavioral science. Throughout, visual mechanisms are investigated from the point of view of the brain functioning at the organismic level, as opposed to the now more prevalent focus on the molecular and cellular levels. This approach allows researchers to deal with the patterns of visually guided behavior of animals in real-life situations.The twenty-six contributions in the book are divided among three sections: "Indentification and Localization Processes in Nonmammalian Vertebrates," introduced by David J. Ingle; "Visual Guidance of Motor Patterns: The Role of Visual Cortex and the Superior Colliculus," introduced by Melvyn A. Goodale; and "Recognition and Transfer Processes," introduced by Richard J. W. Mansfield.The editors are all university researchers in psychology: David J. Ingle at Brandeis, Melvyn A. Goodale at the University of Western Ontario, and Richard J. W. Mansfield at Harvard.

Analysis of visual behavior

Studies of the visual capacity of neurological patients have provided evidence for a dissociation between the perceptual report of a visual stimulus and the ability to direct spatially accurate movements toward that stimulus. Some patients with damage to the parietal lobe, for example, are unable to reach accurately towards visual targets that they unequivocally report seeing. Conversely, some patients with extensive damage to primary visual cortex can make accurate pointing movements or saccades toward a stimulus presented in their 'blind' scotoma. But in investigations of visuomotor control in patients with visual disorders, little consideration has been given to complex acts such as manual prehension. Grasping a three-dimensional object requires knowledge not only of the object's spatial location, but also of its form, orientation and size. We have examined a patient with a profound disorder in the perception of such object qualities. Our quantitative analyses demonstrate strikingly accurate guidance of hand and finger movements directed at the very objects whose qualities she fails to perceive. These data suggest that the neural substrates for the visual perception of object qualities such as shape, orientation and size are distinct from those underlying the use of those qualities in the control of manual skills.

A neurological dissociation between perceiving objects and grasping them

http://mechanism.ucsd.edu/teaching/w12/philneuro/milner.twovisualsystemre-viewed.2008.pdf

Melvyn A. Goodale

Papers

Separate visual pathways for perception and action.

The visual brain in action

Analysis of visual behavior

A neurological dissociation between perceiving objects and grasping them

Two visual systems re-viewed.