There are declines with age in speed of processing, working memory, inhibitory function, and long-term memory, as well as decreases in brain structure size and white matter integrity. In the face of these decreases, functional imaging studies have demonstrated, somewhat surprisingly, reliable increases in prefrontal activation. To account for these joint phenomena, we propose the scaffolding theory of aging and cognition (STAC). STAC provides an integrative view of the aging mind, suggesting that pervasive increased frontal activation with age is a marker of an adaptive brain that engages in compensatory scaffolding in response to the challenges posed by declining neural structures and function. Scaffolding is a normal process present across the lifespan that involves use and development of complementary, alternative neural circuits to achieve a particular cognitive goal. Scaffolding is protective of cognitive function in the aging brain, and available evidence suggests that the ability to use this mechanism is strengthened by cognitive engagement, exercise, and low levels of default network engagement.

/pdf/the-adaptive-brain-aging-and-neurocognitive-scaffolding-3igyn72710.pdf

The Adaptive Brain: Aging and Neurocognitive Scaffolding

Disruption of large-scale brain systems in advanced aging.

Motor Control and Aging: Links to Age-Related Brain Structural, Functional, and Biochemical Effects

The most unexpected and intriguing result from functional brain imaging studies of cognitive aging is evidence for age-related overactivation: greater activation in older adults than in younger adults, even when performance is age-equivalent. Here we examine the hypothesis that age-related overactivation is compensatory and discuss the compensation-related utilization of neural circuits hypothesis (CRUNCH). We review evidence that favors a compensatory account, discuss questions about strategy differences, and consider the functions that may be served by overactive brain areas. Future research directed at neurocognitively informed training interventions may augment the potential for plasticity that persists into the later years of the human lifespan.

Neurocognitive Aging and the Compensation Hypothesis

Faces constitute a unique and widely used category of stimuli. In spite of their importance, there are few collections of faces for use in research, none of which adequately represent the different ages of faces across the lifespan. This lack of a range of ages has limited the majority of researchers to using predominantly young faces as stimuli even when their hypotheses concern both young and old participants. We describe a database of 575 individual faces ranging from ages 18 to 93. Our database was developed to be more representative of age groups across the lifespan, with a special emphasis on recruiting older adults. The resulting database has faces of 218 adults age 18-29, 76 adults age 30-49, 123 adults age 50-69, and 158 adults age 70 and older. These faces may be acquired for research purposes from http://agingmind.cns.uiuc.edu/facedb/. This will allow researchers interested in using facial stimuli access to a wider age range of adult faces than has previously been available.

/pdf/a-lifespan-database-of-adult-facial-stimuli-2hxobt646q.pdf

A lifespan database of adult facial stimuli.

The present study investigated whether neural structures become less functionally differentiated and specialized with age. We studied ventral visual cortex, an area of the brain that responds selectively to visual categories (faces, places, and words) in young adults, and that shows little atrophy with age. Functional MRI was used to estimate neural activity in this cortical area, while young and old adults viewed faces, houses, pseudowords, and chairs. The results demonstrated significantly less neural specialization for these stimulus categories in older adults across a range of analyses.

https://www.pnas.org/content/pnas/101/35/13091.full.pdf

Aging reduces neural specialization in ventral visual cortex

We investigated the hypothesis that increased prefrontal activations in older adults are compensatory for decreases in medial-temporal activations that occur with age. Because scene encoding engages both hippocampal and prefrontal sites, we examined incidental encoding of scenes by 14 young and 13 older adults in a subsequent memory paradigm using functional magnetic resonance imaging (fMRI). Behavioral results indicated that there were equivalent numbers of remembered and forgotten items, which did not vary as a function of age. In an fMRI analysis subtracting forgotten items from remembered items, younger and older adults both activated inferior frontal and lateral occipital regions bilaterally; however, older adults showed less activation than young adults in the left and right parahippocampus and more activation than young adults in the middle frontal cortex. Moreover, correlations between inferior frontal and parahippocampal activity were significantly negative for old but not young, suggesting that those older adults who showed the least engagement of the parahippocampus activated inferior frontal areas the most. Because the analyses included only the unique activations associated with remembered items, these data suggest that prefrontal regions could serve a compensatory role for declines in medial-temporal activations with age.

/pdf/aging-and-the-neural-correlates-of-successful-picture-30jgng9uwb.pdf

Aging and the Neural Correlates of Successful Picture Encoding: Frontal Activations Compensate for Decreased Medial-Temporal Activity

Objective. To evaluate fibromyalgia (FM) patients for the presence of cognitive deficits and to test the hypothesis that abnormalities would fit a model of cognitive aging. Methods. We studied 3 groups of patients: FM patients without concomitant depression and in the absence of medications known to affect cognitive function (n 5 23), age- and education-matched controls (n 5 23), and education-matched older controls who were individually matched to be 20 years older (63 years) than the FM patients (n 5 22). We measured speed of information processing, working memory function, free recall, recognition memory, verbal fluency, and vocabulary. We correlated performance on cognitive tasks with FM symptoms, including depression, anxiety, pain, and fatigue. We also determined if memory complaints were correlated with cognitive performance. Results. As expected, older controls performed more poorly than younger controls on speed of processing, working memory, free recall, and verbal fluency. FM patients performed more poorly than age-matched controls on all measures, with the exception of processing speed. FM patients performed much like older controls, except that they showed better speed of processing and poorer vocabulary. Impaired cognitive performance in FM patients correlated with pain complaints, but not with depressive or anxiety symptoms. FM patients reported more memory problems than did the older and younger controls, and these complaints correlated with poor cognitive performance. Conclusion. Cognitive impairment in FM patients, particularly memory and vocabulary deficits, are documented in this study. Nevertheless, the intact performance on measures of information processing speed suggests that the cognitive deficits are not global. FM patients’ complaints about their memory are likely to be legitimate, since their memory function is not age appropriate.

/pdf/cognitive-function-in-fibromyalgia-patients-1byjr0t8vp.pdf

Cognitive function in fibromyalgia patients

Ophir, Nass, and Wagner (Proceedings of the National Association of Sciences 106:15583-15587, 2009) reported that individuals who routinely engage in multiple forms of media use are actually worse at multitasking, possibly due to difficulties in ignoring irrelevant stimuli, from both external sources and internal representations in memory. Using the media multitasking index (MMI) developed by Ophir et al., we identified heavy media multitaskers (HMMs) and light media multitaskers (LMMs) and tested them on measures of attention, working memory, task switching, and fluid intelligence, as well as self-reported impulsivity and self-control. We found that people who reported engaging in heavy amounts of media multitasking reported being more impulsive and performed more poorly on measures of fluid intelligence than did those who did not frequently engage in media multitasking. However, we could find no evidence to support the contention that HMMs are worse in a multitasking situation such as task switching or that they show any deficits in dealing with irrelevant or distracting information, as compared with LMMs.

/pdf/working-memory-fluid-intelligence-and-impulsiveness-in-heavy-2wqacfe8ex.pdf

Meredith Minear

Papers

A lifespan database of adult facial stimuli.

Aging reduces neural specialization in ventral visual cortex

Aging and the Neural Correlates of Successful Picture Encoding: Frontal Activations Compensate for Decreased Medial-Temporal Activity

Cognitive function in fibromyalgia patients

Working memory, fluid intelligence, and impulsiveness in heavy media multitaskers