M
Metin Ozata
Researcher at Military Medical Academy
Publications - 108
Citations - 7137
Metin Ozata is an academic researcher from Military Medical Academy. The author has contributed to research in topics: Leptin & Hypogonadotropic hypogonadism. The author has an hindex of 38, co-authored 107 publications receiving 6848 citations. Previous affiliations of Metin Ozata include University of Illinois at Chicago.
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Journal ArticleDOI
A leptin missense mutation associated with hypogonadism and morbid obesity.
Journal ArticleDOI
Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects
TL;DR: Due to their long life span, humans who survive the negative effects of leptin deficiency during childhood can, in contrast to ob/ob mice, over decades compensate some of the effects ofptin deficiency on immunity and endocrine function through mechanisms that remain to be elucidated.
Journal ArticleDOI
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
Julio Licinio,Sinan Caglayan,Metin Ozata,Bulent O. Yildiz,Patricia B. de Miranda,F. O'kirwan,Robert Whitby,Liyin Liang,Pinchas Cohen,Shalender Bhasin,Ronald M. Krauss,Johannes D. Veldhuis,Anthony J. Wagner,Alex M. DePaoli,Samuel M. McCann,Ma-Li Wong +15 more
TL;DR: Leptin replacement therapy in leptin-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and noningestive behavior.
Journal ArticleDOI
Increased oxidative stress and hypozincemia in male obesity.
Metin Ozata,Mehmet Mergen,Cagatay Oktenli,Ahmet Aydin,S. Yavuz Sanisoglu,Erol Bolu,M. Ilker Yilmaz,Ahmet Sayal,Askin Isimer,I. Caglayan Ozdemir +9 more
TL;DR: It is concluded that male obesity is associated with defective antioxidant status and hypozincemia, which may have implications in the development of obesity related health problems.
Journal ArticleDOI
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
TL;DR: The results indicate that oxidative status and nitric oxide metabolism are affected in type II diabetes mellitus patients, and suggested that the low cGMP levels in the study may be a good marker of endothelium dysfunction in DM.