Mi-Hyun Lee

TL;DR: Curcumin inhibited OVX‐induced bone loss, at least in part by reducing osteoclastogenesis as a result of increased antioxidant activity and impaired RANKL signaling, suggesting that bone loss associated with estrogen deficiency could be attenuated by curcumin administration.

TL;DR: The data suggest that the inhibitory effect of CO on osteoclastogenesis is caused by impaired RANKL signaling through defective NF-κB activation and reduced levels of long-lasting ROS, which result in decreased bone loss.

TL;DR: The increased fibrinogen level due to loss of ovarian function may contribute, at least partly, to bone loss through the enhanced number and activity of OCs.

TL;DR: DRG2 is associated with survival and cytoskeleton organization of OC under influence of macrophage colony-stimulating factor, and its overexpression leads to elevated bone resorptive activity of OC, resulting in bone loss.

TL;DR: Findings indicate that HVEM regulates bone remodeling via action on OC, and could be due to attenuated osteoclastogenesis and bone resorption resulting from decreased receptor activator of nuclear factor-κB ligand signaling in the OC.