Mi-Sook Kim

TL;DR: Indications are that the extensive tumor cell death due to the direct effect of radiation on tumor cells and the secondary effect through vascular damage may lead to massive release of tumor-associated antigens and various pro-inflammatory cytokines, thereby triggering an anti-tumor immune response.

TL;DR: Indications are that the massive release of tumor antigens from the tumor cells directly and indirectly killed by SBRT and SRS stimulate anti-tumor immunity, thereby suppressing recurrence and metastatic tumor growth.

TL;DR: Irradiation of FSaII tumors with 15 to 30 Gy in a single dose caused dose-dependent secondary cell death, most likely by causing vascular damage accompanied by deterioration of intratumor microenvironment, which may play a crucial role in the control of human tumors with SBRT and SRS.

TL;DR: In addition to directly killing tumor cells, high-dose irradiation used in SBRT and SRS induces indirect tumor cell death via vascular damage and antitumor immunity.

TL;DR: It is suggested that Dmax is a valuable predictor of severe GDT after SBRT using 3 fractionations for abdominopelvic malignancies, especially in patients who receive a high dose to GD.