M
Michael B. Wallace
Researcher at Takeda Pharmaceutical Company
Publications - 33
Citations - 1150
Michael B. Wallace is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Dipeptidyl peptidase & Cancer. The author has an hindex of 10, co-authored 33 publications receiving 1094 citations.
Papers
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Journal ArticleDOI
Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV†
Jun Feng,Zhiyuan Zhang,Michael B. Wallace,Jeffrey A. Stafford,Stephen W. Kaldor,Daniel B. Kassel,Marc Navre,Lihong Shi,Robert J. Skene,Tomoko Asakawa,Koji Takeuchi,Rongda Xu,David R. Webb,Stephen L. Gwaltney +13 more
TL;DR: Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) and related quinazolinone-based DPP-4 inhibitors provide sustained reduction of plasma D PP-4 activity and a lowering of blood glucose in animal models of diabetes.
Patent
Dipeptidyl peptidase inhibitors
Jun Feng,II Stephen L. Escondido Gwaltney,Stephen W. Kaldor,Jeffrey A. Stafford,Michael B. Wallace,Zhiyuan Zhang +5 more
TL;DR: In this paper, pharmaceuticals, kits and methods for use with DPP-IV and other S9 proteases that comprise a compound comprising of CO, SO, SO 2, and C═NR 9 are described.
Journal ArticleDOI
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer
Qing Dong,Douglas R. Dougan,Xianchang Gong,Petro Halkowycz,Bohan Jin,Toufike Kanouni,Shawn M. O’Connell,Nicholas Scorah,Lihong Shi,Michael B. Wallace,Feng Zhou +10 more
TL;DR: A novel 5-phenylamino-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione series of MEK inhibitors has been developed using structure-based drug design and lead optimization of this series led to the discovery of TAK-733.
Journal ArticleDOI
Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV
Zhiyuan Zhang,Michael B. Wallace,Jun Feng,Jeffrey A. Stafford,Robert J. Skene,Lihong Shi,Bumsup Lee,Kathleen Aertgeerts,Andrew John Jennings,Rongda Xu,Daniel B. Kassel,Stephen W. Kaldor,Marc Navre,David R. Webb,Stephen L. Gwaltney +14 more
TL;DR: Two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyridinediones, are discovered and provide sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.
Patent
Mapk/erk kinase inhibitors
Qing Dong,Xianchang Gong,Stephen W. Kaldor,Toufike Kanouni,Nicholas Scorah,Michael B. Wallace,Feng Zhou +6 more
TL;DR: In this article, the following compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined in this formula: variables are defined as defined by the authors.