M
Michael Cornfeldt
Publications - 19
Citations - 557
Michael Cornfeldt is an academic researcher. The author has contributed to research in topics: Quinuclidinyl Benzilate & Elevated plus maze. The author has an hindex of 10, co-authored 19 publications receiving 544 citations.
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Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats : a potential model for obsessive compulsive disorder
TL;DR: Since obsessive-compulsive disorder (OCD) and polydipsic behavior both involve excessive expression of a normal behavior, thepolydipsia model may be relevant for the prediction of compounds useful in the treatment of OCD.
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9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.
Gregory M. Shutske,Pierrat Frank A,Kevin J. Kapples,Michael Cornfeldt,Mark R. Szewczak,Francis P. Huger,Gina M. Bores,Vahram Haroutunian,Kenneth L. Davis +8 more
TL;DR: These compounds are related to 1,2,3,4-tetrahydro-9-acridinamine and inhibit acetylcholinesterase in vitro and are active in a model that may be predictive of activity in Alzheimer's disease--the scopolamine-induced impairment of 24-h memory of a passive dark-avoidance paradigm in mice.
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GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures.
TL;DR: The results show that GABAergic agents that facilitate GABA transmission are effective following systemic administration in non-conditioned anxiety procedures and may indicate potential therapeutic efficacy in certain anxiety states.
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Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents
Robert W. Dunn,Denise M. Flanagan,Lawrence L. Martin,Lisa L. Kerman,Anne T. Woods,Fernando Camacho,Carole A. Wilmot,Michael Cornfeldt,Richard C. Effland,Paul L. Wood,Roy Corbett +10 more
TL;DR: The data suggest that R-(+)-HA-966, an antagonist at the strychnine-insensitive glycine/NMDA receptor site, was anxioselective and lacked some of the side-effects associated with benzodiazepine anxiolytics.