M
Michaël D. B. Fenster
Researcher at Max Planck Society
Publications - 8
Citations - 482
Michaël D. B. Fenster is an academic researcher from Max Planck Society. The author has contributed to research in topics: Latrunculin & Total synthesis. The author has an hindex of 7, co-authored 7 publications receiving 468 citations.
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Journal ArticleDOI
Total Syntheses of the Actin‐Binding Macrolides Latrunculin A, B, C, M, S and 16‐epi‐Latrunculin B
Alois Fürstner,Dominic De Souza,Laurent Turet,Michaël D. B. Fenster,Liliana Parra-Rapado,Cornelia Wirtz,Richard Mynott,Christian W. Lehmann +7 more
TL;DR: A previously unknown acid-catalyzed degradation pathway of these bioactive natural products is described, with cysteine-derived ketone 18, the tetrahydropyranyl segment 31 serving as the common synthesis platform for the preparation of all naturally occurring latrunculins.
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Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere†
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Toward the total synthesis of spirastrellolide A. Part 1: Strategic considerations and preparation of the southern domain.
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Latrunculin Analogues with Improved Biological Profiles by “Diverted Total Synthesis”: Preparation, Evaluation, and Computational Analysis
Alois Fürstner,Douglas Kirk,Michaël D. B. Fenster,Christophe Aïssa,Dominic De Souza,Cristina Nevado,Tell Tuttle,Walter Thiel,Oliver Müller +8 more
TL;DR: This study attests to the maturity of ring-closing alkyne metathesis (RCAM) catalyzed by a molybdenum alkylidyne complex generated in situ, which constitutes a valuable tool for advanced organic synthesis and natural product chemistry.
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Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties
Alois Fürstner,Douglas Kirk,Michaël D. B. Fenster,Christophe Aïssa,Dominic De Souza,Oliver Müller +5 more
TL;DR: The discovery that the removal of the methyl branches decorating the macrocycle in 2 engenders a significant increase in potency, while streamlining the synthesis to a considerable extent attests to the maturity of alkyne metathesis.