Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency causes anemia, a major public health burden worldwide. On the other extreme, iron accumulation in critical organs such as liver, heart, and pancreas causes organ dysfunction due to the generation of oxidative stress. Therefore, systemic iron levels must be tightly balanced. Here we focus on the regulatory role of the hepcidin/ferroportin circuitry as the major regulator of systemic iron homeostasis. We discuss how regulatory cues (e.g., iron, inflammation, or hypoxia) affect the hepcidin response and how impairment of the hepcidin/ferroportin regulatory system causes disorders of iron metabolism.

https://www.mdpi.com/2072-6643/5/8/3034/pdf

Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

Management of Hemorrhage in Cardiothoracic Surgery

Rationale: The high costs of health care in the United States and other developed nations are attributable, in part, to overuse of tests, treatments, and procedures that provide little to no benefit for patients. To improve the quality of care while also combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of the top five medical services that patients and physicians should question.Objectives: To present the Critical Care Societies Collaborative’s Top 5 list in Critical Care Medicine and describe its development.Methods: Each professional society in the Collaborative nominated members to the Choosing Wisely task force, which established explicit criteria for evaluating candidate items, generated lists of items, performed literature reviews on each, and sought external input from content experts. Task force members narrowed the list to the Top 5 items using a standardized scoring system ba...

/pdf/an-official-american-thoracic-society-american-association-4cmoge9iuw.pdf

An official American Thoracic Society/American Association of Critical-Care Nurses/American College of Chest Physicians/Society of Critical Care Medicine policy statement: the Choosing Wisely® Top 5 list in Critical Care Medicine.

Anemia and mortality in acute coronary syndromes: A systematic review and meta-analysis

Background
Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan.

/pdf/association-between-ischemic-stroke-and-iron-deficiency-4j0w9yj13a.pdf

Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study

https://www.internationaljournalofcardiology.com/article/S0167-5273(12)00008-3/pdf

Michael Garfinkle

Papers

Anemia and mortality in acute coronary syndromes: A systematic review and meta-analysis

Red blood cell transfusion and mortality among patients hospitalized for acute coronary syndromes: A systematic review