Michael Gerckens

TL;DR: This review summarises the available data about the structure and function of the pulmonary ECM, and highlights changes that occur in idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and lung cancer.

TL;DR: The highest benefit of the 3D-LTC ex vivo model is its close representation of the in situ human lung in respect of 3D tissue architecture, cell type diversity and lung anatomy as well as the potential for assessment of tissue from individual patients, which is relevant to further develop novel strategies for precision medicine.

TL;DR: A panel of stable surface markers in human lung fibroblasts is identified, applicable for positive-cell isolation directly from lung tissue, and complex surface protein changes during fibroblast-myofibroblast activation are identified.

TL;DR: 3 cases of coronavirus disease 2019 occurring in patients shortly after thoracotomy and thoracoscopy procedures are reported, illustrating the imminent threat of severe acute respiratory syndrome coronav virus 2 infection for thoracic surgery patients.

TL;DR: This study reveals the convergence of spatially and transcriptionally distinct fibroblast lineages into transcriptionally uniform myofibroblasts and identifies Sfrp1 as an autocrine inhibitor of fibro Blast invasion during early stages of fibrogenesis.