Cleḿence Queffeĺec,† Marc Petit,†,‡ Pascal Janvier,† D. Andrew Knight, and Bruno Bujoli*,† †LUNAM Universite,́ CNRS, UMR 6230, Chimie Et Interdisciplinarite:́ Synthes̀e Analyse Modeĺisation (CEISAM), UFR Sciences et Techniques, 2, rue de la Houssinier̀e, BP 92208, 44322 NANTES Cedex 3, France ‡Universite ́ Pierre et Marie Curie (UPMC), CNRS, UMR7201, Institut Parisien De Chimie Molećulaire (IPCM), 4 place Jussieu, 75252 Paris Cedex 05, France Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901, United States

Surface modification using phosphonic acids and esters.

Engineering biocompatible implant surfaces

Effects of topography and composition of titanium surface oxides on osteoblast responses.

Metal or metal oxide nanoparticles possess unique features compared to equivalent larger-scale materials. For applications, it is often necessary to stabilize or functionalize such nanoparticles. Thus, modification of the surface of nanoparticles is an important chemical challenge. In this survey, various possibilities are discussed how nanoparticles can be protected by organic ligands and how these ligands can be used to introduce functionalities. The preparative possibilities include grafting of an already functionalized ligand on the nanoparticle surface, exchanging part or all existing ligands on the nanoparticle surface, or grafting of a ligand on a nanoparticle followed by modification by organic chemical reactions.

Surface modification and functionalization of metal and metal oxide nanoparticles by organic ligands

Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO2 coatings on titanium

Commercially pure titanium (cp Ti) is widely used in dental implantology. However, it is only passively integrated in bone and the resulting fixation in the bone, which is necessary for the function, is mainly mechanical in its nature. With the objective of increasing the chemical interaction between the implant and bone tissue, several phosphonic acids were synthesized and grafted onto titanium disks. The bare polished Ti disks (Ti P) and the grafting of three phosphonic acids (methylenediphosphonic acid (MDP), propane-1,1,3,3-tetraphosphonic acid (PTP), and ethane-1,1,2-triphosphonic acid (ETP)) on these disks were characterized with X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). These surface analytical techniques provided strong indications of the formation of a chemical link between the Ti implant and the phosphonic acid molecule. The bioactivity of the modified Ti disks was evaluated by incubating these disks in a physiological solution (Hank's ...

Michael Grätzel

Papers

Surface Modification of Titanium with Phosphonic Acid To Improve Bone Bonding: Characterization by XPS and ToF-SIMS