M
Michael H. Brooke
Researcher at Washington University in St. Louis
Publications - 62
Citations - 7188
Michael H. Brooke is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Duchenne muscular dystrophy & Carnitine. The author has an hindex of 29, co-authored 62 publications receiving 7013 citations. Previous affiliations of Michael H. Brooke include St. Louis Children's Hospital & Vanderbilt University.
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Journal ArticleDOI
Muscle Fiber Types: How Many and What Kind?
TL;DR: The purpose of the present communication is to point out some of the problems involved in the classification of fibers and to add new information of value in the analysis of human biopsy material.
Journal ArticleDOI
THREE "MYOSIN ADENOSINE TRIPHOSPHATASE" SYSTEMS: THE NATURE OF THEIR pH LABILITY AND SULFHYDRYL DEPENDENCE
TL;DR: Two types of striated muscle fibers (Padykula amid Herman) can be distimiguished and these have been described as the less active type I and the more active type II fibers.
Journal ArticleDOI
Randomized, double-blind six-month trial of prednisone in Duchenne's muscular dystrophy
Jerry R. Mendell,Richard T. Moxley,Robert C. Griggs,Michael H. Brooke,G. M. Fenichel,J.P. Miller,Wendy King,Linda Signore,Shree Pandya,J. Florence,J. Schierbecker,J. Robison,K. Kaiser,Stephen Mandel,C. Arfken,B. Gilder +15 more
TL;DR: It is concluded from this six-month study that prednisone improves the strength and function of patients with Duchenne's muscular dystrophy, however, further research is required to identify the mechanisms responsible for these improvements and to determine whether prolonged treatment with corticosteroids may be warranted despite their side effects.
Journal ArticleDOI
Clinical trial in duchenne dystrophy. I. The design of the protocol
Michael H. Brooke,Robert C. Griggs,Jerry R. Mendell,Gerald M. Fenichel,Jack B. Shumate,Richard J. Pellegrino +5 more
TL;DR: A protocol has been designed which selects patients with Duchenne muscular dystrophy and permits accurate measurement of their status and an integral part of the protocol is a system for checking on the consistency of the data obtained using a computer program.
Journal ArticleDOI
Clinical investigation in duchenne dystrophy: 2. Determination of the “power” of therapeutic trials based on the natural history
Michael H. Brooke,Gerald M. Fenichel,Robert C. Griggs,Mendell,Richard T. Moxley,J. P. Miller,Michael A. Province +6 more
TL;DR: A prospective study of 114 patients with DMD provided data for “power” calculations for future therapeutic trials and fifteen percent of the patients appear to have a milder variety of the disease and are termed “outliers.”