M
Michael H. Silber
Researcher at Mayo Clinic
Publications - 183
Citations - 13880
Michael H. Silber is an academic researcher from Mayo Clinic. The author has contributed to research in topics: REM sleep behavior disorder & Restless legs syndrome. The author has an hindex of 55, co-authored 172 publications receiving 12531 citations. Previous affiliations of Michael H. Silber include University of Rochester.
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Journal ArticleDOI
Narcolepsy associated with other central nervous system disorders
TL;DR: Patients with the coexistence of narcolepsy and another CNS disorder seen between 1975 and 1998 at their institution were identified, andHypothalamic–pituitary pathology was the most common association.
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MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies
Melissa E. Murray,Tanis J. Ferman,Bradley F. Boeve,Scott A. Przybelski,Timothy G. Lesnick,Amanda M. Liesinger,Matthew L. Senjem,Jeffrey L. Gunter,Gregory M. Preboske,Val J. Lowe,Prashanthi Vemuri,Brittany N. Dugger,David S. Knopman,Glenn E. Smith,Joseph E. Parisi,Michael H. Silber,Neill R. Graff-Radford,Ronald C. Petersen,Clifford R. Jack,Dennis W. Dickson,Kejal Kantarci +20 more
TL;DR: Investigation of structural MRI and digital microscopic characteristics of REM sleep behavior disorder in individuals with low-, intermediate-, and high-likelihood dementia with Lewy bodies at autopsy found presence of pRBD is associated with a higher likelihood of DLB and less severe Alzheimer-related pathology in the medial temporal lobes, whereas absence of p RBD is characterized by Alzheimer-like atrophy patterns on MRI and increased phospho-tau burden.
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Analysis of hypocretin (orexin) antibodies in patients with narcolepsy.
John L. Black,Michael H. Silber,Lois E. Krahn,Paul A. Fredrickson,V. Shane Pankratz,Rajeswari Avula,Denise L. Walker,Nancy L. Slocumb +7 more
TL;DR: These ELISA assay results do not support the hypothesis that HLA DQB1*0602-positive narcolepsy with cataplexy is associated with serum antibodies against preprohypocretin or its cleavage products.
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Current management of sleep disturbances in dementia.
TL;DR: This review describes how each symptom may relate to the dementing illnesses themselves, which primary sleep disorders may be at play, which medications employed for dementia may impact on the symptom, the role of depression in that symptom, and how circadian dysrhythmias can underlie that symptom.
Journal ArticleDOI
Characterizing the emotions that trigger cataplexy.
TL;DR: A 51-item questionnaire succeeds in identifying cataplexy in narcolepsy-catapLexy patients measured up against a comparison group and could subsequently be included into screening tools for use with different patient populations.