Michael Haberl

TL;DR: Investigation of the expression of CYP3A5 and its genetic determinants in a panel of 183 Caucasian liver samples reports that a SNP within intron 3 (g.6986G>A) is the primary cause of the CYP4A5 protein polymorphism, and should add to efforts to identify clinically relevant, CYP2A5-specific reactions and to further elucidate traits responsible for variable expression of the entire CYP 3A family.

TL;DR: The identification of a new member of the CYP3A family and the characterization of the full CYP 3A locus will aid efforts to identify the genetic variants underlying its variable expression, which will lead to a better optimization of therapies involving the numerous substrates of CYP2A proteins.

TL;DR: A CYP2A6*1A-like allele, *9B and *12B are major genetic determinants of CYP 2A6 phenotype variation in Caucasians, and a haplotype almost identical to allele *1A was associated with decreased expression and activity of CYp2A 6 compared to all other haplotypes.

TL;DR: The data are consistent with a functional relevance of CYP3A4*1B and with selection against this allele in non-African populations and with the elimination of CYp3A5*2B involved different parts of the CYP 3A locus in European Caucasians and Asians.