J
Jürgen Brockmöller
Researcher at University of Göttingen
Publications - 246
Citations - 23783
Jürgen Brockmöller is an academic researcher from University of Göttingen. The author has contributed to research in topics: Genotype & Gene. The author has an hindex of 76, co-authored 237 publications receiving 22081 citations. Previous affiliations of Jürgen Brockmöller include Goethe University Frankfurt & University of Vienna.
Papers
More filters
Journal ArticleDOI
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
Sven Hoffmeyer,Oliver Burk,O. von Richter,H. P. Arnold,Jürgen Brockmöller,Andreas Johne,Ingolf Cascorbi,Thomas Gerloff,Ivar Roots,Eichelbaum Michel,Ulrich Brinkmann +10 more
TL;DR: A significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function is observed and this polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of M DR-1.
Journal Article
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
TL;DR: A solid basis is provided for prediction of CYP2D6 capacity, as required in drug research and routine drug treatment, and significant differences in enzymatic activity measured by the dextromethorphan metabolic ratio (MR) are shown.
Journal ArticleDOI
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines
Andrea Antal,Ivan Alekseichuk,Marom Bikson,Jürgen Brockmöller,Andre R. Brunoni,Robert Chen,L.G. Cohen,G. Dowthwaite,Jens Ellrich,Jens Ellrich,Agnes Flöel,Felipe Fregni,Mark S. George,Roy H. Hamilton,Jens Haueisen,Christoph Herrmann,Friedhelm C. Hummel,Jean-Pascal Lefaucheur,David Liebetanz,Colleen Loo,Colin D. McCaig,Carlo Miniussi,Pedro C. Miranda,Vera Moliadze,M.A. Nitsche,M.A. Nitsche,R. Nowak,Frank Padberg,Alvaro Pascual-Leone,W. Poppendieck,Simona Rossi,Paolo Maria Rossini,John C. Rothwell,Maria Adele Rueger,Giulio Ruffini,K. Schellhorn,Hartwig R. Siebner,Yoshikazu Ugawa,Anna Wexler,Ulf Ziemann,Mark Hallett,Walter Paulus +41 more
TL;DR: Structured interviews are provided and recommend their use in future controlled studies, in particular when trying to extend the parameters applied, to discuss recent regulatory issues, reporting practices and ethical issues.
Journal ArticleDOI
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
Julia Kirchheiner,K. Nickchen,Michael Bauer,Ma-Li Wong,Julio Licinio,Ivar Roots,Jürgen Brockmöller +6 more
TL;DR: Combinations of polymorphisms in pharmacokinetic and pharmacodynamic pathways of relevance might contribute to identify genotypes associated with best and worst responders and they may also identify susceptibility to adverse drug reactions.
Journal ArticleDOI
Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
TL;DR: The A/A genotype may either be a direct cause of increased CYP1A2 activity, or be genetically linked to polymorphisms conferring high inducibility, and further studies are needed to define the role of this polymorphism on the pharmacokinetics of drugs metabolised by CYP 1A2 and in the activation of carcinogens.