M
Michael Hombach
Researcher at University of Zurich
Publications - 62
Citations - 2206
Michael Hombach is an academic researcher from University of Zurich. The author has contributed to research in topics: Enterobacter cloacae & Population. The author has an hindex of 24, co-authored 62 publications receiving 1856 citations. Previous affiliations of Michael Hombach include Hoffmann-La Roche.
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Journal ArticleDOI
Identification of Gram-Positive Cocci by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry: Comparison of Different Preparation Methods and Implementation of a Practical Algorithm for Routine Diagnostics
Bettina Schulthess,Katharina Brodner,Guido V. Bloemberg,Reinhard Zbinden,Erik C. Böttger,Michael Hombach +5 more
TL;DR: The Bruker MALDI Biotyper system using the direct transfer-formic acid sample preparation method was shown to be a highly reliable tool for the identification of Gram-positive cocci.
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Practical Approach for Reliable Detection of AmpC Beta-Lactamase-Producing Enterobacteriaceae
Silke Polsfuss,Guido V. Bloemberg,Jacqueline Giger,Vera Meyer,Erik C. Böttger,Michael Hombach +5 more
TL;DR: A comprehensive diagnostic flow chart for the detection of AmpC production is proposed consisting of a simple phenotypic screening and a single phenotypesic confirmation test with inconclusive results being resolved by molecular analysis.
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Prosthetic Valve Endocarditis and Bloodstream Infection Due to Mycobacterium chimaera
Yvonne Achermann,Matthias Rössle,Matthias Hoffmann,Vanessa Deggim,Stefan P. Kuster,Dieter R. Zimmermann,Guido V. Bloemberg,Michael Hombach,Barbara Hasse +8 more
TL;DR: In this article, a case of prosthetic valve endocarditis and one case of bloodstream infection caused by Mycobacterium chimaera (M.chimaera) was reported.
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Development and Validation of the Elecsys Anti-SARS-CoV-2 Immunoassay as a Highly Specific Tool for Determining Past Exposure to SARS-CoV-2.
Peter Muench,Simon Jochum,Verena Wenderoth,Beatus Ofenloch-Haehnle,Michael Hombach,Matthias Strobl,Henrik Sadlowski,Christopher Sachse,Giulia Torriani,Isabella Eckerle,Alexander Riedel +10 more
TL;DR: The Elecsys Anti-SARS-CoV-2 immunoassay demonstrated high sensitivity (99.5% at ≥14 days post-PCR confirmation) and specificity (98.6 to 99.80%), supporting its use as a tool for identification of past SARS- covirus 2 infection, including use in populations with low disease prevalence.
Journal ArticleDOI
Detection of AmpC Beta-Lactamase in Escherichia coli: Comparison of Three Phenotypic Confirmation Assays and Genetic Analysis
S. Peter-Getzlaff,Silke Polsfuss,M. Poledica,Michael Hombach,Jacqueline Giger,Erik C. Böttger,Reinhard Zbinden,Guido V. Bloemberg +7 more
TL;DR: This study analyzed clinical E. coli isolates with reduced susceptibility to amoxicillin-clavulanic acid, piperacillin-tazobactam, or extended-spectrum cephalosporins for the presence of AmpC production and found three phenotypic AmpC confirmation assays were able to detect the majority of ampC-positive strains correctly.