M
Michael I. Trenell
Researcher at Newcastle University
Publications - 167
Citations - 10868
Michael I. Trenell is an academic researcher from Newcastle University. The author has contributed to research in topics: Fatty liver & Randomized controlled trial. The author has an hindex of 46, co-authored 162 publications receiving 8342 citations. Previous affiliations of Michael I. Trenell include Leeds General Infirmary & University of Sydney.
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Journal ArticleDOI
A study of physical activity comparing people with Charcot-Marie-Tooth disease to normal control subjects.
Gita Ramdharry,Alexander J. Pollard,Robert Grant,E Dewar,Matilde Laura,Sarah A. Moore,Kate Hallsworth,Thomas Ploetz,Michael I. Trenell,Mary M. Reilly +9 more
TL;DR: Compared to healthy controls, people with Charcot-Marie-Tooth disease had a lower step count over seven days, but exhibited more frequent transitions from sedentary to active behaviors, and high Body Mass Index and increased time spent sedentary were related factors that have implications for general health status.
Journal ArticleDOI
Feasibility of a Very Low Calorie Diet to Achieve a Sustainable 10% Weight Loss in Patients With Nonalcoholic Fatty Liver Disease.
Jadine Scragg,Leah Avery,Sophie Cassidy,Guy S. Taylor,Laura Haigh,Marie Boyle,Michael I. Trenell,Quentin M. Anstee,Stuart McPherson,Kate Hallsworth +9 more
TL;DR: VLCD offers a feasible treatment option for some patients with NAFLD to enable a sustainable ≥10%, weight loss, which can improve liver health, cardiovascular risk, and quality of life in those completing the intervention.
Journal ArticleDOI
RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial.
L. Jopson,Julia L. Newton,Jeremy M. Palmer,Achilleas Floudas,John D. Isaacs,Jessica Qian,Jennifer Wilkinson,Michael I. Trenell,Andrew M. Blamire,Denise Howel,David Jones +10 more
TL;DR: The study aims to assess whether rituximab improves fatigue in patients with PBC, the safety, and tolerability of ritUXimab in PBC and the sustainability of any beneficial actions.
Journal ArticleDOI
Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression
Grainne S. Gorman,Emma L. Blakely,Hue-Tran Hornig-Do,Helen A. L. Tuppen,Laura C. Greaves,Langping He,Angela Baker,Gavin Falkous,Jane Newman,Michael I. Trenell,Bryan Lecky,Richard K. Petty,Douglass M. Turnbull,Robert McFarland,Robert W. Taylor +14 more
TL;DR: The data indicate that the mechanism underlying the expression of the biochemical defect may involve a compensatory response to the novel MTND1 gene mutations, promoting assembly factor up-regulation and stabilization of respiratory chain super-complexes, resulting in partial rescue of the clinical phenotype.
Journal ArticleDOI
The effect of aerobic versus resistance exercise training on peak cardiac power output and physical functional capacity in patients with chronic heart failure.
Djordje G. Jakovljevic,Djordje G. Jakovljevic,David Nunan,Sarah McDonagh,Michael I. Trenell,Richard Grocott-Mason,David A. Brodie +6 more
TL;DR: This review of autopsies in military recruits over a 25-year period found that the number of sudden death in young adults diagnosed with coronary heart disease has changed little in the past 25 years, despite an increase in the severity of the disease.