M
Michael J. Barnes
Researcher at University of Cambridge
Publications - 52
Citations - 4749
Michael J. Barnes is an academic researcher from University of Cambridge. The author has contributed to research in topics: Integrin & Collagen receptor. The author has an hindex of 29, co-authored 51 publications receiving 4526 citations. Previous affiliations of Michael J. Barnes include Brigham and Women's Hospital.
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Journal ArticleDOI
Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen.
C.G. Knight,Laurence F. Morton,David J. Onley,Anthony R. Peachey,Tatsuo Ichinohe,Minoru Okuma,Richard W. Farndale,Michael J. Barnes +7 more
TL;DR: Peptides consisting of a repeat Gly-Pro-Hyp sequence are potent platelet agonists and could provide a basis for a highly-specific anti-thrombotic reagent to control thrombosis associated with plaque rupture.
Journal ArticleDOI
Collagens and atherosclerosis.
TL;DR: Effects as summarized in this short review, are not always, at first sight, consistent and should be kept in mind, though, when considering the response of a cell to collagen.
ComponentDOI
Structure of the Integrin alpha2beta1-binding Collagen Peptide.
TL;DR: A comparison of IBP and IBP(c) main-chain conformation reveals the flexible nature of the triple helix backbone in the imino-poor GFOGER region, which could be important to the integrin-collagen interaction.
Journal ArticleDOI
Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.
Laurence F. Morton,Anthony R. Peachey,Lynn S. Zijenah,A H Goodall,Martin J. Humphries,Michael J. Barnes +5 more
TL;DR: Little if any adhesion occurred to any denatured species at 37 degrees C, demonstrating the importance of the collagen helix, and bivalent-cation-independent binding to fibres of three main platelet surface proteins, 90, 150 and 190 kDa in size was revealed.