Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

https://www.zora.uzh.ch/id/eprint/77770/1/physiol_rev_93.pdf

About sleep's role in memory

Many important research hypotheses concern conditional relations in which the effect of one predictor varies with the value of another. Such relations are commonly evaluated as multiplicative interactions and can be tested in both fixed- and random-effects regression. Often, these interactive effects must be further probed to fully explicate the nature of the conditional relation. The most common method for probing interactions is to test simple slopes at specific levels of the predictors. A more general method is the Johnson-Neyman (J-N) technique. This technique is not widely used, however, because it is currently limited to categorical by continuous interactions in fixed-effects regression and has yet to be extended to the broader class of random-effects regression models. The goal of our article is to generalize the J-N technique to allow for tests of a variety of interactions that arise in both fixed- and random-effects regression. We review existing methods for probing interactions, explicate the analytic expressions needed to expand these tests to a wider set of conditions, and demonstrate the advantages of the J-N technique relative to simple slopes with three empirical examples.

/pdf/probing-interactions-in-fixed-and-multilevel-regression-3i87wa3tl9.pdf

Probing Interactions in Fixed and Multilevel Regression: Inferential and Graphical Techniques

Although the functions of sleep remain largely unknown, one of the most exciting hypotheses is that sleep contributes importantly to processes of memory and brain plasticity. Over the past decade, a large body of work, spanning most of the neurosciences, has provided a substantive body of evidence supporting this role of sleep in what is becoming known as sleep-dependent memory processing. We review these findings, focusing specifically on the role of sleep in (a) memory encoding, (b) memory consolidation, (c) brain plasticity, and (d) memory reconsolidation; we finish with a summary of the field and its potential future directions.

/pdf/sleep-memory-and-plasticity-5a8thdeyh4.pdf

Sleep, memory, and plasticity.

Cognitive neuroscience continues to build meaningful connections between affective behavior and human brain function. Within the biological sciences, a similar renaissance has taken place, focusing on the role of sleep in various neurocognitive processes and, most recently, on the interaction between sleep and emotional regulation. This review surveys an array of diverse findings across basic and clinical research domains, resulting in a convergent view of sleep-dependent emotional brain processing. On the basis of the unique neurobiology of sleep, the authors outline a model describing the overnight modulation of affective neural systems and the (re)processing of recent emotional experiences, both of which appear to redress the appropriate next-day reactivity of limbic and associated autonomic networks. Furthermore, a rapid eye movement (REM) sleep hypothesis of emotional-memory processing is proposed, the implications of which may provide brain-based insights into the association between sleep abnormalities and the initiation and maintenance of mood disturbances.

/pdf/overnight-therapy-the-role-of-sleep-in-emotional-brain-41mamer3l0.pdf

Overnight therapy? The role of sleep in emotional brain processing.

Converging evidence and new research methodologies from across the neurosciences permit the neuroscientific study of the role of sleep in off-line memory reprocessing, as well as the nature and function of dreaming. Evidence supports a role for sleep in the consolidation of an array of learning and memory tasks. In addition, new methodologies allow the experimental manipulation of dream content at sleep onset, permitting an objective and scientific study of this dream formation and a renewed search for the possible functions of dreaming and the biological processes subserving it.

https://www.cogsci.ucsd.edu/~pineda/COGS175/readings/Stickgold.pdf

Michael J. McGrath

Papers

REM sleep facilitation of adaptive waking behavior: a review of the literature.

Self-management treatment of smoking behavior

REM drive and function: a study of the interactive effects of personality and presleep condition.