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Michael J. Wargovich
Researcher at University of Texas Health Science Center at San Antonio
Publications - 155
Citations - 7213
Michael J. Wargovich is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 44, co-authored 155 publications receiving 6901 citations. Previous affiliations of Michael J. Wargovich include National Institutes of Health & Dartmouth College.
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Journal Article
Chemoprevention of N-Nitrosomethylbenzylamine-induced Esophageal Cancer in Rats by the Naturally Occurring Thioether, Diallyl Sulfide
TL;DR: DAS totally inhibited tumor formation in rats treated with a carcinogenic dose of NMBA and was found to substantially reduce hepatic microsomal metabolism of the carcinogen, demonstrating that DAS is unique in its anticarcinogenic activity.
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Diallyl sulfide, a flavor component of garlic (allium sativum), inhibits dimethyihydrazine-induced colon cancer
TL;DR: Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adenocarcinoma induced by 20 weekly injections of 1,2-dimethylhydrazine.
Journal Article
Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
TL;DR: Data indicate that the allyl group coupled to a single sulfur atom might play an important structural role in inhibition of DMH-induced colonic nuclear toxicity and carcinogenesis, and might assist in detoxification of carcinogens and could be necessary for some aspects of chemoprevention.
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Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression.
Michael J. Wargovich,Arnaldo Jimenez,Kathy McKee,Vernon E. Steele,Marco A. De Velasco,Johnnie Woods,Roger E. Price,Kenneth N. Gray,Gary J. Kelloff +8 more
TL;DR: Certain phytochemicals, antihistamines, non-steroidal anti-inflammatory drugs and retinoids show unique preclinical promise for chemoprevention of colon cancer, with the latter two drug classes particularly effective in the post-initiation phase of carcinogenesis.
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Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin)
TL;DR: The results of this study suggest that these herbal supplements may exert significant and potentially beneficial effects on decreasing the amount of precancerous lesions and inducing apoptosis in the large intestine.