Michael L. Hess

TL;DR: It is suggested that the common pathway leading to intracellular calcium overload in the oxygen paradox and ischemic/reperfusion injury and to a lesser extent the calcium paradox involves the generation of oxygen free radicals.

TL;DR: It is concluded that PGH synthase and lipoxygenase produce superoxide via a side-chain reaction dependent on the presence of suitable reducing cosubstrate, analogous to that described for peroxidases in general.

TL;DR: This thesis highlights several novel therapeutic strategies aimed at interrupting the oxygen free radical mediated component of ischaemia/reperfusion injury and points out and emphasises the growing importance of the role of singlet oxygen.

TL;DR: Results show that most of the nitroblue terrazolium reduction was accounted for by superoxide anion radical generated in the course of arachidonate metabolism via the cyclooxygenase pathway, and the most likely explanation for these findings is that increased metabolism of exogenous or endogenous archidonate via cyclo oxygengenase results in the appearance of superoxideAnion radical in cerebral extracellular space.

TL;DR: The discovery of the enzyme superoxide dismutase that catalyzed the production of hydrogen peroxide from superoxide anion defined the new field of oxygen metabolism in biologic systems and a potential role of oxidation/reduction reactions in both physiologic and pathologic conditions.