M
Michael Müller-Steinhardt
Researcher at Heidelberg University
Publications - 51
Citations - 1314
Michael Müller-Steinhardt is an academic researcher from Heidelberg University. The author has contributed to research in topics: Cytokine & Whole blood. The author has an hindex of 22, co-authored 50 publications receiving 1242 citations. Previous affiliations of Michael Müller-Steinhardt include University of Lübeck & German Red Cross.
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Journal ArticleDOI
The interleukin-6 -174promoter polymorphism is associated with long-term kidney allograft survival
TL;DR: Genotyping of the IL-6 -174polymorphism may offer a new method for identifying patients at increased risk of allograft loss, since the clinical impact on transplant outcome seems as important as matching for histocompatibility antigens.
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Evaluation of a Novel Mononuclear Cell Isolation Procedure for Serological HLA Typing
Peter Schlenke,Harald Klüter,Michael Müller-Steinhardt,Hans Jörg Hammers,Kerstin Borchert,Gregor Bein +5 more
TL;DR: The isolation of PBMC by the CPT method resulted in a higher yield and improved purity compared to those obtained with the standard gradient technique, and the decreasing viability after 48 h limits the use of both methods for HLA typing and HLA antibody screening.
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Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect.
Christoph Härtel,Nina Schumacher,Lutz Fricke,Brigitte Ebel,Holger Kirchner,Michael Müller-Steinhardt +5 more
TL;DR: The results suggest an individual degree of calcineurin inhibitor sensitivity of activated whole-blood lymphocytes based on IL-2 mRNA expression is possible in patients undergoing tacrolimus or CsA monotherapy before living-donor kidney transplantation.
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Does histocompatibility affect homograft valve function after the Ross procedure
J.F. Matthias Bechtel,Claus Bartels,Claudia Schmidtke,Wim Skibba,Michael Müller-Steinhardt,Harald Klüter,Hans-Hinrich Sievers +6 more
TL;DR: Implantation of a cryopreserved pulmonary homograft during the Ross procedure can induce a specific humoral response and a significant increase of the transhomograft pressure gradients within 15±6 months after surgery, but it was unable to demonstrate a relationship between this increase and the degree of histoincompatibility.
Journal ArticleDOI
Cooperative Influence of the Interleukin‐6 Promoter Polymorphisms –597, –572 and –174 on Long‐Term Kidney Allograft Survival
Michael Müller-Steinhardt,Lutz Fricke,Brigitte Müller,Brigitte Ebel,Holger Kirchner,Christoph Härtel +5 more
TL;DR: It is shown that the −597 and −174 polymorphism are in tight‐linkage disequilibrium and that homozygous carriers of the GGG−597/−572/−174 haplotype (GGG/GGG genotype) have superior 3‐year graft survival rates compared with the 8.0‐fold increased risk of premature graft loss in all other patients.