Showing papers in "Kidney International in 2002"

TL;DR: A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.

TL;DR: Compared with calcium-based phosphate binders, sevelamer is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients.

TL;DR: The hypothesis that increased oxidative stress and its sequalae is a major contributor to increased atherosclerosis and cardiovascular morbidity and mortality found in uremia is proposed and it is proposed that retained uremic solutes such as beta-2 microglobulin, advanced glycosylated end products, cysteine, and homocysteine further contribute to the pro-atherogenic milieu of Uremia.

TL;DR: Intensive BP control in normotensive type 2 diabetic patients: (1) slowed the progression to incipient and overt diabetic nephropathy; (2) decreased the progression of diabetic retinopathy; and (3) diminished the incidence of stroke.

TL;DR: Large differences in vascular access use exist between EUR and the US, even after adjustment for patient characteristics, and the results strongly suggest that a facility's preferences and approaches to vascular access practice are major determinants of vascularAccess use.

TL;DR: Implementing these measures is likely to increase the prevalence of fistulas in any given dialysis unit, however, differences among dialysis units are likely to persist because of differences in gender, race, and co-morbidity mix of the patient population.

TL;DR: Recent improvements in graft half-life are related to conservation of renal function within the first year post-transplantation, and one-year creatinine and Delta Creatinine values predict long-term renal graft survival.

TL;DR: Mild to moderate loss of renal function is strongly associated with an increased risk of cardiovascular mortality and does not appear to involve common risk factors such as hypertension, diabetes or hyperhomocysteinemia.

TL;DR: It is proposed that the "extension phase" of ischemic ARF involves alterations in renal perfusion, continued hypoxia, and inflammatory processes that all contribute to continued tubular cell injury.

TL;DR: Self-reported depression by two simple questions was associated with increased risks of mortality and hospitalization for hemodialysis patients.

TL;DR: FGF-2 makes an important contribution to the mechanisms of EMT by stimulating microenvironmental proteases essential for disaggregation of organ-based epithelial units and the expression of epithelial and mesenchymal marker proteins seems to be affected at the promoter level.

TL;DR: In this article, the authors analyzed the decline rates of residual renal function (rGFR) prospectively in 522 incident HD and PD patients who had structured follow-up assessments.

TL;DR: In patients with ESRD undergoing renal transplantation, vascular calcification of the medial layer of the inferior epigastric artery is common, can be detected by spiral CT, and is associated with deposition of bone matrix proteins.

TL;DR: Venous catheters are associated with an increased risk of all-cause and infection-related mortality among hemodialysis patients.

TL;DR: This study confirms that several readily-measured nutritional indicators predict mortality among hemodialysis patients and that changes in indicator values over six months provide additional important prognostic information.

TL;DR: The results suggest that, via transition to a mesenchymal phenotype, TEC can produce ECM proteins in human disease and directly intervene in the fibrotic processes.

TL;DR: Calciphylaxis is no longer rare, it is usually nonulcerating and can be diagnosed clinically in all patients, and these patients have a high mortality, especially once ulceration occurs, therefore the disease may be preventable.

TL;DR: Ang II in vivo increases TNF-alpha production in the kidney and up-regulates other proinflammatory mediators, including IL-6, MCP-1 and NF-kappaB, coincidentally associated to the presence of glomerular and interstitial inflammatory cells in the kidneys.

TL;DR: PTDM is associated with an unfavorable cardiovascular risk profile that precedes the development of hyperglycemia and is an independent predictor of reduced survival in renal allograft recipients.

TL;DR: Pyridoxamine inhibits the progression of renal disease, and decreases hyperlipidemia and apparent redox imbalances in diabetic rats, supporting a mechanism of action involving AGE/ALE inhibition.

TL;DR: Survival in children with ESRD has increased over the last 20 years, but the SMR remains high; early transplantation and a more vigorous approach toward hypertension and infection may be mandatory in order to further reduce mortality.

TL;DR: Early proteinuric diabetic nephropathy increases renal expression of the p47phox component of NAD(P)H oxidase and eNOS with increased indices of systemic and renal oxidative/nitrosative stress, which indicates a pathogenic role for AT1 receptors in the development of oxidative damage in the kidneys during early DM.

TL;DR: Hypocholesterolemia was an independent predictor of death in patients on chronic hemodialysis and was only evident in a subgroup of patients whose serum albumin was more than 4.5 g/dL.

TL;DR: Reductions in BP with NHD are accompanied by regression of LVH, and there was no relationship between changes in LVMI and changes in BP or Hb in the CHD cohort.

TL;DR: Pre- and post-dialysis blood pressure values have independent associations with mortality, in a way that implicates wide pulse pressures, and large interdialytic weight gains are associated with shorter survival when comorbidity is taken into account.

TL;DR: ARF is common in ICU patients and has a persistent negative impact on outcomes, although the majority of ARF is not severe enough to require dialysis support, and APACHE III predicted outcome very well in patients with no renal failure and patients with ARF at the time of scoring but underpredicted mortality in those who developed ARF after ICU admission and overestimated mortality in patients as well.

TL;DR: A proteome map of normal human urine was constructed as a reference protein database by using two differential fractionated techniques to isolate the proteins and predicted glycosylation to be the most common explanation for multiple forms of the same protein.

TL;DR: The uremic sera-induced osteopontin expression in BVSMC is partially mediated through alkaline phosphatase activity and a Na/Pi co-transport dependent mechanism, however, other non-Na/Pi dependent mechanisms also contribute to accelerated vascular calcification in patients with ESRD.

TL;DR: The association between moderate renal insufficiency and cardiovascular disease, demonstrated in other epidemiologic studies, appears to be due to co-occurrence of renal insUFFiciency with traditional cardiovascular risk factors.

TL;DR: Findings indicate a striking reversal of renal glycosphingolipid accumulation in the vasculature and in other renal cell types, and suggest that long-term treatment with r-halphaGalA may halt the progression of pathology and prevent renal failure in patients with Fabry disease.