M
Michael P. Wachter
Researcher at Johnson & Johnson Pharmaceutical Research and Development
Publications - 70
Citations - 1132
Michael P. Wachter is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Aryl & Moiety. The author has an hindex of 20, co-authored 70 publications receiving 1107 citations. Previous affiliations of Michael P. Wachter include Johnson & Johnson.
Papers
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Journal Article
RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.
Scott Wadsworth,Druie Cavender,Scott Beers,P. Lalan,Peter H. Schafer,Elizabeth A. Malloy,Wei Wu,Bohumila Fahmy,Gilbert C. Olini,Janet E. Davis,J. L. Pellegrino-Gensey,Michael P. Wachter,John Siekierka +12 more
TL;DR: RWJ 67657 inhibited the enzymatic activity of recombinant p38alpha and beta, but not gamma or delta, in vitro and had no significant activity against a variety of other enzymes, based on these favorable biological properties.
Patent
Substituted imidazoles useful in the treatment of inflammatory diseases.
TL;DR: In this article, a series of substituted imidazoles of Formula (I) is described, which are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
Journal ArticleDOI
1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.
Zhihua Sui,Jihua Guan,Michael Paul Ferro,Kathy McCoy,Michael P. Wachter,William V. Murray,Monica Singer,Michele Steber,Dave M. Ritchie,Dennis C. Argentieri +9 more
TL;DR: Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2 and SAR of both phenyl rings in 1 and 2, and the aliphatic ring in 1 will be discussed.
Patent
Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
TL;DR: In this paper, a method of pyrazoles preparation, compositions containing the same and methods of their use are disclosed, which are useful in alleviating inflammatory and cardiovascular disorders in mammals.
Journal ArticleDOI
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Peter J. Connolly,Steven K. Wetter,Kimberly N. Beers,Stephanie C. Hamel,Robert Chen,Michael P. Wachter,Justin Ansell,Monica Singer,Michele Steber,David M. Ritchie,Dennis C. Argentieri +10 more
TL;DR: Two series of compounds having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5- LO inhibitor ABT-761 were prepared and many of these hybrid compounds are potent COX and 5-LO inhibitors.