Michael Papamichail

TL;DR: It is demonstrated that at low NK‐to‐MSC ratios, MSCs alter the phenotype of NK cells and suppress proliferation, cytokine secretion, and cyto‐toxicity against HLA‐class I– expressing targets.

TL;DR: The optimal culture conditions for the successful isolation and expansion of human MSCs in high numbers for subsequent cellular therapeutic approaches are defined.

TL;DR: Investigating whether a combination of mesenchymal stem cells capable of differentiating into cardiac myocytes and endothelial progenitors that mainly promote neoangiogenesis might be able to facilitate tissue repair in myocardial scars found it feasible, safe, and may contribute to regional regeneration of myocardIAL tissue early or late following MI.

TL;DR: An improved flow cytometric method that is able to measure cytotoxicity, based on two fluorescent dyes, is developed and used to quantify natural killer and lymphokine-activated killer activities against human K562 and Daudi cell lines and the murine YAC-1 and L1210 cell lines respectively.

TL;DR: In conclusion, repetitive infusions of allogeneic, in vitro activated and expanded with IL-15/HC NK cells, in combination with chemotherapy are safe and potentially clinically effective.