M
Michael R. Rosen
Researcher at Columbia University
Publications - 337
Citations - 13332
Michael R. Rosen is an academic researcher from Columbia University. The author has contributed to research in topics: Purkinje fibers & Repolarization. The author has an hindex of 61, co-authored 337 publications receiving 13015 citations. Previous affiliations of Michael R. Rosen include Indiana University & State University of New York System.
Papers
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Journal ArticleDOI
Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.
Dan M. Roden,Ralph Lazzara,Michael R. Rosen,Peter J. Schwartz,Jeffry Towbin,G. Michael Vincent +5 more
TL;DR: The identification of disease genes in LQTS represents a major milestone in understanding the mechanisms underlying this disease but also presents new opportunities for combined research at the molecular, cellular, and clinical levels to understand issues such as adrenergic regulation of cardiac electrophysiology and mechanisms of susceptibility to arrhythmias in L QTS and other settings.
Journal ArticleDOI
The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology.
Wilhelm Haverkamp,Günter Breithardt,Alan John Camm,Michiel J. Janse,Michael R. Rosen,Charles Antzelevitch,Denis Escande,Michael R. Franz,Marek Malik,Arthur J. Moss,R. Shah +10 more
TL;DR: The scientific and clinical basis of drug-induced QT prolongation and proarrhythmia was summarized by formal presentations and selected topics were discussed in detail in separate workshops.
Journal ArticleDOI
The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.
Wilhelm Haverkamp,Günter Breithardt,A. J. Camm,Michiel J. Janse,Michael R. Rosen,Charles Antzelevitch,Denis Escande,Michael R. Franz,Marek Malik,Arthur J. Moss,R. Shah +10 more
TL;DR: The scientific and clinical basis of drug-induced QT prolongation and pro-arrhythmia was summarised by formal presentations and selected topics were discussed in detail in separate workshops.
Journal ArticleDOI
Mechanisms of digitalis toxicity. Effects of ouabain on phase four of canine Purkinje fiber transmembrane potentials.
TL;DR: The presence of phase 4 depolarization in the form of LAP may cause an impairment of conduction which is dependent on cycle length, and whether O-induced increases in phase 4 slope result in automaticity or LAP depends on interrelationships between RMP, TP, and level of membrane potential reached during phase 4.
Journal ArticleDOI
The relationship of human atrial cellular electrophysiology to clinical function and ultrastructure.
L Mary-Rabine,Adelin Albert,Tuan Duc Pham,Allan J. Hordof,John J. Fenoglio,James R. Malm,Michael R. Rosen +6 more
TL;DR: The likelihood of occurrence of arrhythmias can be predicted using the analytic method described and the relationship between hemodynamic anomalies and resultant changes in both human atrial fiber structure and electrical function is emphasized.