Michael R. Shurin

TL;DR: It is confirmed by showing that rats exposed to electric footshock, physical restraint, or a conditioned aversive stimulus have increased levels of plasma IL-6, and the kinetics of the increase resembled that of increase in plasma corticosterone, which suggests that increased plasmaIL-6 may be part of the hormonal responses to stress.

TL;DR: Better understanding of DC immunobiology in cancer is pivotal for designing novel or improved therapeutic approaches that will allow proper functioning of DCs in patients with cancer.

TL;DR: Microenvironmental IL-1β is defined as a master cytokine in tumor progression using a model of orthotopically introduced 4T1 breast cancer cells and the combination of anti–IL-1 β plus anti–PD-1 abrogated the tumors completely.

TL;DR: It is demonstrated that NB-derived gangliosides inhibit the generation of functionally active DCs and may play a role in tumor-induced immunosuppression and subsequent tumor escape from immune recognition and elimination.

TL;DR: Successful interventions to regulate Thl/Th2 balance and modify the immune response may decrease the risk of development or relapse of malignancy, avoid impairment of donor cell engraftment, and allow successful fetal maturation.