M
Michael T. Migawa
Researcher at Isis Pharmaceuticals
Publications - 65
Citations - 2895
Michael T. Migawa is an academic researcher from Isis Pharmaceuticals. The author has contributed to research in topics: Oligonucleotide & Nucleic acid. The author has an hindex of 27, co-authored 64 publications receiving 2427 citations.
Papers
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Journal ArticleDOI
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
Eric E. Swayze,Andrew M. Siwkowski,Edward Wancewicz,Michael T. Migawa,Tadeusz K. Wyrzykiewicz,Gene Hung,Brett P. Monia,and C. Frank Bennett +7 more
TL;DR: It is suggested that while LNA ASOs have the potential to improve potency, they impose a significant risk of hepatotoxicity.
Journal ArticleDOI
Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.
Punit P. Seth,Guillermo Vasquez,Charles A. Allerson,Andres Berdeja,Hans Gaus,Garth A. Kinberger,Thazha P. Prakash,Michael T. Migawa,Balkrishen Bhat,Eric E. Swayze +9 more
TL;DR: Biophysical evaluation of the cMOE- and cEt-containing oligonucleotides revealed that they possess hybridization and mismatch discrimination attributes similar to those of LNA but greatly improved resistance to exonuclease digestion.
Journal ArticleDOI
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
Wen Shen,Cheryl L De Hoyos,Michael T. Migawa,Timothy A. Vickers,Hong Sun,Audrey Low,Thomas A. Bell,Meghdad Rahdar,Swagatam Mukhopadhyay,Christopher E. Hart,Melanie Bell,Stan Riney,Susan F. Murray,Sarah Greenlee,Rosanne M. Crooke,Xue-hai Liang,Punit P. Seth,Stanley T. Crooke +17 more
TL;DR: Introduction of a single 2′-O-methyl (2′-OMe) modification at gap position 2 reduced protein-binding, substantially decreasing hepatotoxicity and improving the therapeutic index with minimal impairment of antisense activity.
Patent
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
TL;DR: In this paper, the authors presented 5'-substituted-2'-F nucleoside analogs for enhancing properties of oligomeric compounds including nuclease resistance, which are useful for enhancing the properties of NER.
Patent
Bicyclic cyclohexose nucleic acid analogs
TL;DR: In this paper, the authors provided bicyclic cyclohexose nucleoside analogs for enhancing properties of oligomeric compounds including nuclease resistance, and these analogs were used for enhancing the properties of nucleosides.