Michael W. DeLucia

TL;DR: Transgenic models that express Abeta1-40 or Abeta2-42 in the absence of human amyloid beta protein precursor (APP) overexpression establish that Abeta 1-42 is essential for amyloids deposition in the parenchyma and also in vessels.

TL;DR: The results suggest that AD/ALB is pathologically different from AD/LBD, suggesting that it is a neuropathologically distinct and isolated &agr;-synucleinopathy.

TL;DR: The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age and found that nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-SYN pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus.

TL;DR: A previously unreported kindred with HDLS with individuals presenting as CBD is described, and immunohistochemistry for APP and αB-crystallin demonstrates distinctive neurodegeneration in cerebral axons and perikarya.

TL;DR: The results indicate that even a single icv administration of the recombinant enzyme can have significant clinical impact and suggests that other lysosomal storage disorders with significant CNS involvement may similarly benefit.