Michael W. Rooney

TL;DR: Tourniquet‐induced limb exsanguination for limb surgery may be a useful ischemia‐reperfusion model to investigate the presence of oxidants, particularly H2 O2 and xanthine oxidase activity.

TL;DR: Oxygen supply to the brain and myocardium is maintained at the expense of oxygen supply to less critical organs and, during combined isovolemic hemodilution and adenosine−induced hypotension, oxygen is oversupplied to theMyocardium but undersupplied toThe brain and kidney.

TL;DR: It is demonstrated in anesthetized dogs that 1) myocardial oxygenation is well maintained during isovolemic hemodilution alone and, 2) my Cardiac Oxygenation is influenced favorably when isovolution is combined with adenosine-induced controlled hypotension.

TL;DR: Oxygen supply to the brain and myocardium is maintained at the expense of oxygen supply to less critical organs during isovolemic hemodilution, and this pattern of regional circulatory response during he modilution remains intact in the presence of high-grade beta-adrenergic blockade with propranolol.

TL;DR: The studies suggest that the indications for the use of calcium should depend on the initial serum level of ionized calcium, and that the effects of calcium administration on myocardial performance and peripheral vasoconstriction in normocalcemic and hypocalcemic states should be separated.