Michael W. Schmidtke

TL;DR: Findings indicate that CL is required for optimal PDH activation, generation of acetyl-CoA, and TCA cycle function, findings that link the key mitochondrial lipid CL to T CA cycle function and energy metabolism.

TL;DR: It is reported that signaling and anaplerotic metabolic pathways that supplement defects in the TCA cycle are essential in crd1Δ mutant cells, suggesting that TCA Cycle deficiency caused by the absence of CL necessitates activation of anaplerosis pathways to replenish acetyl-CoA and T CA cycle intermediates.

TL;DR: In this paper, the effects of Prostate (VPA) on cellular metabolism were investigated using the yeast model and it was shown that the drug upregulated expression of genes normally repressed during logarithmic growth on glucose medium and increased levels of activated (phosphorylated) Snf1 kinase, the major metabolic regulator of these genes.

TL;DR: In this article, a new perspective wherein mood stabilizers exert their therapeutic mechanism by activating the unfolded protein response (UPR) pathway was presented, which is supported by reported abnormalities in the UPR pathway in lymphoblasts from bipolar disorder patients.

TL;DR: The authors regret to report an error in Table 1 of this publication that the mating type of yeast strain BY4741 should have been listed as MATa rather than MATα as printed.