Showing papers by "Michaela Vorlíčková published in 2003"
TL;DR: The study showed that d(GGGA)(5) and d(GGA)(7) associated into homoduplexes but were prone to guanine tetraplex formation, especially in the presence of KCl, and the ordered single strands provided strikingly similar CD spectra, indicating that all of the conformers shared similar base stacking geometries.
22 citations
TL;DR: It is shown using polyacrylamide gel electrophoresis that guanine+adenine repeat strands of DNA associate into homoduplexes at neutral pH and moderate ionic strength, which has implications for the nature of the first replicators, as well as regarding forces stabilizing the duplexes of DNA.
Abstract: We show using polyacrylamide gel electrophoresis that guanine+adenine repeat strands of DNA associate into homoduplexes at neutral pH and moderate ionic strength. The homoduplexes melt in a cooperative way like the Watson-Crick duplex, although they contain no Watson-Crick base pair. Guanine is absolutely needed for the homoduplex formation and the homoduplex stability increases with the guanine content of the repeat. The present results have implications for the nature of the first replicators, as well as regarding forces stabilizing the duplexes of DNA.
13 citations