M
Michal Hocek
Researcher at Academy of Sciences of the Czech Republic
Publications - 367
Citations - 8308
Michal Hocek is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA & DNA polymerase. The author has an hindex of 46, co-authored 353 publications receiving 7424 citations. Previous affiliations of Michal Hocek include Charles University in Prague & Humboldt State University.
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C-nucleosides: synthetic strategies and biological applications.
TL;DR: While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed hydrolysis of the nucleosidic bond, their C-analogues are much more stable and have found numerous applications in medicinal chemistry and chemical biology.
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Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.
TL;DR: The Suzuki−Miyaura reaction of protected 6-chloropurine and 2-amino-6-chlorOPurine bases and nucleosides with substituted phenylboronic acids led to the corresponding protected 6-(substituted phenyl)purine derivatives 6−9, and their deprotection yielded a series of substituted 6-phenylpurine bases, nucleoside, and ribonucleosides 10−13.
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Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.
Michal Hocek,Petr Nauš,Radek Pohl,Ivan Votruba,Phillip A. Furman,Phillip M. Tharnish,Michael J. Otto +6 more
TL;DR: Significant anti-HCV activity of 6-hetarylpurine ribonucleosides has been discovered and is reported here for the first time and compared with cytostatic effect.
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Nucleobase modification as redox DNA labelling for electrochemical detection
Michal Hocek,Miroslav Fojta +1 more
TL;DR: Basic aspects of DNA electrochemistry with a strong focus on the use of modified nucleobases as redox probes for electrochemical bioanalysis are reviewed.
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Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids.
Michal Hocek,Miroslav Fojta +1 more
TL;DR: The combination of cross-coupling of NTPs with polymerase incorporation gives an efficient and straightforward two-step synthesis of modified nucleic acids.