Michel Journet

TL;DR: A series of structural analogs of the Pseudomonas aeruginosa autoinducer obtained and tested for their ability to act as autoinducers in stimulating the expression of the gene for elastase by measuring beta-galactosidase production from a lasB-lacZ gene fusion in the presence of the transcriptional activator LasR suggest that the length of the acyl side chain of theautoinducer molecule is the most critical factor for activity.

TL;DR: A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described, leading to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield.

TL;DR: In this paper, the formylation of lithium acetylides with DMF led to α,β-acetylenic aldehydes in excellent yields (>94%) using a reverse quench into a phosphate buffer (10% aqueous KH 2 PO 4,4 equiv).

TL;DR: A highly efficient, asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine, is described, which features the first application of iminium organocatalysis on an industrial scale.

TL;DR: In this article, the α-cyclopropyl radical which is involved in the Stork-Beckwith mechanism of the 5-versus-6-membered ring formation in the vinyl radical cyclization was intercepted.