D
Dongwei Cai
Researcher at Merck & Co.
Publications - 51
Citations - 1324
Dongwei Cai is an academic researcher from Merck & Co.. The author has contributed to research in topics: Yield (chemistry) & Catalysis. The author has an hindex of 18, co-authored 51 publications receiving 1283 citations.
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Journal ArticleDOI
An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids.
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Dongwei Cai,Robert D. Larsen,Paul J. Reider +6 more
TL;DR: 3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench", and this technique was further studied and evaluated on other aryl halides in the preparation of aRYlboronic acids.
Journal ArticleDOI
Asymmetric Synthesis of MK-0499
David M. Tschaen,Lee Abramson,Dongwei Cai,Richard Desmond,Ulf-H. Dolling,Lisa F. Frey,Sandor Karady,Yao-Jun Shi,Thomas R. Verhoeven +8 more
Journal ArticleDOI
A practical synthesis of a COX-2-specific inhibitor.
Ian W. Davies,Jean-François Marcoux,Edward G. Corley,Michel Journet,Dongwei Cai,Michael Palucki,Jimmy Ming-Tai Wu,Robert D. Larsen,Kai Rossen,Philip J. Pye,Lisa DiMichele,Peter G. Dormer,Paul J. Reider +12 more
TL;DR: A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described, leading to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield.
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Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Gary Javadi,Dongwei Cai,Robert D. Larsen +6 more
TL;DR: This work has reported an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle with a catalytic amount of palladium.
Journal ArticleDOI
Highly efficient synthesis of α,β-acetylenic aldehydes from terminal alkynes using DMF as the formylating reagent
TL;DR: In this paper, the formylation of lithium acetylides with DMF led to α,β-acetylenic aldehydes in excellent yields (>94%) using a reverse quench into a phosphate buffer (10% aqueous KH 2 PO 4,4 equiv).