M
Michele A. Kercher
Researcher at Howard Hughes Medical Institute
Publications - 3
Citations - 439
Michele A. Kercher is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: GTPase-activating protein & Heterotrimeric G protein. The author has an hindex of 3, co-authored 3 publications receiving 419 citations. Previous affiliations of Michele A. Kercher include Yale University.
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Journal ArticleDOI
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å
Kevin C. Slep,Michele A. Kercher,Wei He,Christopher W. Cowan,Christopher W. Cowan,Theodore G. Wensel,Paul B. Sigler +6 more
TL;DR: Crystal structures of the R GS9 RGS domain reveal insights into effector activation, synergistic GTPase acceleration, RGS9 specificity and RGS activity.
Journal ArticleDOI
Prediction and confirmation of a site critical for effector regulation of RGS domain activity.
Mathew E. Sowa,Wei He,Kevin C. Slep,Michele A. Kercher,Michele A. Kercher,Olivier Lichtarge,Theodore G. Wensel,Theodore G. Wensel +7 more
TL;DR: These results demonstrate the effectiveness of ET for identifying binding sites and efficiently focusing mutational studies on their key residues, thereby linking raw sequence and structure data to functional information.
Journal ArticleDOI
Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation
Kevin C. Slep,Michele A. Kercher,Thomas Wieland,Ching-Kang Chen,Melvin I. Simon,Paul B. Sigler +5 more
TL;DR: The 2.9 Å crystal structure of the enigmatic, neuronal G protein Gαo in the GTP hydrolytic transition state, complexed with RGS16 is presented, affording insight to receptor, GAP and effector specificity.