M
Michele Zampieri
Researcher at Sapienza University of Rome
Publications - 44
Citations - 1956
Michele Zampieri is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 22, co-authored 38 publications receiving 1651 citations. Previous affiliations of Michele Zampieri include Pasteur Institute.
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Journal ArticleDOI
Reconfiguration of DNA methylation in aging
Michele Zampieri,Fabio Ciccarone,Roberta Calabrese,Claudio Franceschi,Alexander Bürkle,Paola Caiafa,Paola Caiafa +6 more
TL;DR: A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5 hmC.
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Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns
Paola Caiafa,Paola Caiafa,Tiziana Guastafierro,Tiziana Guastafierro,Michele Zampieri,Michele Zampieri +5 more
TL;DR: It is hypothesize that the right nuclear balance between unmodified and PARylated poly(ADP‐ribose) polymerase 1 (PARP‐1), which depends on the dynamics of PARPs/PARG activity, is key to maintaining genomic methylation pattern.
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Modulation of DNMT1 activity by ADP-ribose polymers.
TL;DR: It is shown that DNMT1 is able to bind long and branched ADP-ribose polymers in a noncovalent way and suggested that this complex is catalytically inefficient in DNA methylation.
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DNA methylation and chromatin structure: the puzzling CpG islands
Paola Caiafa,Michele Zampieri +1 more
TL;DR: The aim is to gather some mechanisms regarding this intriguing enigma regarding the mechanism(s) whereby CpG islands, which remain protected from methylation in normal cells, are susceptible tomethylation in tumor cells.
Journal ArticleDOI
DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
TL;DR: Age-related variations of methylcytosine and its oxidative derivatives in relation to the dynamics of chromatin structure, histone post-translational modifications and their modulators are described.