M
Michiko Yoshii
Researcher at Hiroshima University
Publications - 29
Citations - 402
Michiko Yoshii is an academic researcher from Hiroshima University. The author has contributed to research in topics: Bile acid & Chenodeoxycholic acid. The author has an hindex of 7, co-authored 28 publications receiving 373 citations.
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Journal ArticleDOI
Endoplasmic Reticulum Stress Induces Leptin Resistance
Toru Hosoi,Miyako Sasaki,Tsuyoshi Miyahara,Chie Hashimoto,Suguru Matsuo,Michiko Yoshii,Koichiro Ozawa +6 more
TL;DR: It is suggested that the pathological mechanism of leptin resistance is derived from ER stress, which was mediated through protein tyrosine phosphatase 1B but not through suppressors of cytokine signaling 3.
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Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells
TL;DR: It is suggested that the leptin-induced expression of GRP78 may be dependent on the PI3K-mTOR pathway, thereby protecting against ER stress associated with obesity.
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Bile Alcohol Proffles in Bile, Urine, and Feces of a Patient with Cerebrotendinous Xanthomatosis
Kazuhiro Shimazu,Miho Kuwabara,Michiko Yoshii,Kenji Kihira,Haruo Takeuchi,Ikuta Nakano,Susumu Ozawa,Makoto Onuki,Yashio Hatta,Takahiko Hoshita +9 more
TL;DR: Although the bile alcohol profile in urine was quite different from those in bile and feces, the determination of urinary bilecohols as well as of biliary and fecal bile Alcohols could be used for diagnosis of cerebrotendinous xanthomatosis.
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Synthesis of new bile salt analogues, sodium 3 alpha, 7 alpha-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha, 7 beta-dihydroxy-5 beta-cholane-24-sulfonate.
TL;DR: The chemical synthesis of two new bile salt analogues, namely sodium 3 alpha,7 alpha-dihydroxy-5 beta-cholane-24-sulfonate from chenodeoxycholic acid and ursodeoxyCholic acid, respectively, are described.
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Bile acid profiles in a peroxisomal D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency.
Mizuho Une,Masaki Konishi,Yasuyuki Suzuki,Shinjiro Akaboshi,Michiko Yoshii,Taiju Kuramoto,Kingo Fujimura +6 more
TL;DR: As in such several peroxisomal disorders as Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease, the accumulation of C27-bile acid intermediates was also demonstrated in the infant with D-bifunctional protein deficiency.