M
Michio Matsuhashi
Researcher at University of Tokyo
Publications - 101
Citations - 5442
Michio Matsuhashi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Escherichia coli & Penicillin binding proteins. The author has an hindex of 37, co-authored 101 publications receiving 5338 citations. Previous affiliations of Michio Matsuhashi include Tokai University.
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Molecular cloning of the gene of a penicillin-binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus.
Michio Matsuhashi,Min Dong Song,Fumitoshi Ishino,Masaaki Wachi,M. Doi,M. Inoue,Kimiko Ubukata,N Yamashita,Masatoshi Konno +8 more
TL;DR: A novel penicillin-binding protein, PBP-2' (Mr about 75,000), is known to be induced in excessively large amount by most beta-lactam compounds in cells of a clinically isolated strain of Staphylococcus aureus, TK784, that is highly resistant to beta- lactams and also most other antibiotics.
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Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.
TL;DR: Probably the MRSA PBP evolved by recombination of two genes: an inducible type I penicillinase gene and a PBP gene of a bacterium, causing the formation of a β‐lactam‐inducible MRSAPBP.
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Lipid-phosphoacetylmuramyl-pentapeptide and lipid-phosphodisaccharide-pentapeptide: presumed membrane transport intermediates in cell wall synthesis.
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Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli.
TL;DR: A chromosomal region of Escherichia coli contiguous to the fabE gene at 71 min on the chromosomal map contains multiple genes that are responsible for determination of the rod shape and sensitivity to the amidinopenicillin mecillinam.
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Role of Lipopolysaccharides in Antibiotic Resistance and Bacteriophage Adsorption of Escherichia coli K-12
TL;DR: Novobiocin-supersensitive mutants, with incomplete LPS, lacking phosphates in their backbone structure were found to be resistant to phage T4, and those which also lacked heptose wereresistant to phages T4 and T7.