M
Mihaela-Loredana Vlad
Researcher at Romanian Academy
Publications - 6
Citations - 75
Mihaela-Loredana Vlad is an academic researcher from Romanian Academy. The author has contributed to research in topics: Internal medicine & Immunology. The author has an hindex of 3, co-authored 3 publications receiving 38 citations.
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Journal ArticleDOI
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis
Simona-Adriana Manea,Mihaela-Loredana Vlad,Ioana Madalina Fenyo,A.G. Lazar,Monica Raicu,Horia Muresian,Maya Simionescu,Adrian Manea +7 more
TL;DR: Collectively, HDAC inhibition reduced atherosclerotic lesion progression in ApoE−/− mice, possibly by intertwined mechanisms involving negative regulation of Nox expression and inflammation.
Journal ArticleDOI
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Mihaela-Loredana Vlad,Simona-Adriana Manea,A.G. Lazar,Monica Raicu,Horia Muresian,Maya Simionescu,Adrian Manea +6 more
TL;DR: The expression pattern of key histone acetyltransferase subtypes in human atherosclerosis is investigated to determine their role in mediating the upregulation of Nox5 in macrophages under inflammatory conditions and to suggest the existence of a new epigenetic mechanism underlying oxidative stress in Atherosclerosis.
Journal ArticleDOI
Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe.
Simona-Adriana Manea,Mihaela-Loredana Vlad,Daniela Rebleanu,A.G. Lazar,Ioana Madalina Fenyo,Manuela Calin,Maya Simionescu,Adrian Manea +7 more
TL;DR: In this article, the cell-impermeant ROS Brite™ 700 (RB700) probe that produces bright near-infrared fluorescence upon ROS oxidation was encapsulated into VCAM-1-targeted, sterically stabilized liposomes (VLp).
Journal ArticleDOI
Monocyte-derived macrophages mediate S100a8/A9-induced oxidative stress and inflammation in the ischemic myocardium
Mihaela-Loredana Vlad,Razvan Gheorghita Mares,A.G. Lazar,Simona-Adriana Manea,B. Preda,MibaeIa Simionescu,Alexandru Schiopu,Adrian Manea +7 more
TL;DR: In this paper , the role of macrophages (Mac) as potential cellular effectors of S100A8/A9 in MI was investigated, and the authors found that the effect was suppressed by ABR-238901.
Journal ArticleDOI
VLA4-Enhanced Allogeneic Endothelial Progenitor Cell-Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes
Alexandru Filippi,Alina Constantin,Nicoleta Alexandru,Cristina Ana Mocanu,Mihaela-Loredana Vlad,Ioana Madalina Fenyo,Agneta Simionescu,Dan T. Simionescu,Ileana Manduteanu,Adriana Georgescu +9 more
TL;DR: The experiments show that genetically modified allogeneic EPCs might be a safe treatment option, with bioavailability in the desired target compartments and the ability to preserve aortic valve function in dyslipidemia and diabetes.