M
Mikhail Bogdanov
Researcher at University of Texas Health Science Center at Houston
Publications - 93
Citations - 4962
Mikhail Bogdanov is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Membrane protein & Phosphatidylethanolamine. The author has an hindex of 36, co-authored 86 publications receiving 4407 citations. Previous affiliations of Mikhail Bogdanov include University of Texas at Austin & University of Texas System.
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A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition.
TL;DR: Results demonstrate that membrane protein topology once attained can be changed in a reversible manner in response to alterations in phospholipid composition, and may be subject to post‐assembly proofreading to correct misfolded structures.
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Lipid-Dependent Membrane Protein Topogenesis
William Dowhan,Mikhail Bogdanov +1 more
TL;DR: The membrane translocation potential of negative amino acids working in opposition to the positive-inside rule is largely dampened by the normal presence of phosphatidylethanolamine, thus explaining the dominance of positive residues as retention signals.
Journal ArticleDOI
Lipid-assisted protein folding.
Mikhail Bogdanov,William Dowhan +1 more
TL;DR: The role individual lipids play as part of the protein folding machinery has been largely ignored and the factors and mech-anism driving correct folding of integral membrane proteins arelargely unknown.
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A phospholipid acts as a chaperone in assembly of a membrane transport protein
TL;DR: A mutant of Escherichia coli lacking phosphatidylethanolamine (PE) and a monoclonal antibody directed against a conformationally sensitive epitope (4B1) of lactose permease were used to establish a novel role for a phospholipid in the assembly of a membrane protein.
Journal ArticleDOI
Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates
Brandon K. Tan,Mikhail Bogdanov,Jinshi Zhao,William Dowhan,Christian R. H. Raetz,Ziqiang Guan +5 more
TL;DR: The combined YmdB-ClsC gene pair used PE as the phosphatidyl donor to PG to form CL, which demonstrates a third and unique mode for CL synthesis.