Mikhail Stepanichev

TL;DR: A gradually developing oxidative stress was evident in the hippocampus of rats treated with Abeta(25-35) as indicated by the increase in 2-thiobarbituric acid (TBARS) reactive substances and superoxide generation, suggesting the involvement of oxidative stress in Abeta-induced neurodegeneration and a relation between memory impairment and neurodegenersation in the CA1 subfield of the hippocampus.

TL;DR: The present review focuses on the numerous experimental rodent models of depression induced by different stress factors during early life (including prenatal period) or adulthood, giving emphasis to the data on the changes of neurotrophic factors and neuroinflammatory indices in the brain.

TL;DR: It is hypothesized that increased synthesis of NO induced by A beta(25-35) is related to qualitative alterations of nNOS molecule, but not to changes in NOS protein expression, as well as the mechanisms of neurodegenerative diseases including Alzheimer's disease.

TL;DR: In this paper, the effects of neonatal proinflammatory stress on the development of anxiety and depressive-like behavior, stress responsiveness, hippocampal plasticity and conditioned fear response were studied in adolescent and adult male Wistar rats.

TL;DR: Surprisingly, administration of TNFα into the cerebral ventricles prevented this Aβ(25–35)‐induced increase in hippocampal caspase‐3 activity, and the results are discussed from the perspective of dual (neuroprotective and neurodestructive) roles of T NF in the brain.