M
Milena Simovic
Researcher at German Cancer Research Center
Publications - 8
Citations - 77
Milena Simovic is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Chromothripsis & DNA damage. The author has an hindex of 2, co-authored 4 publications receiving 47 citations.
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Journal ArticleDOI
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Manasi Ratnaparkhe,John Wong,Pei-Chi Wei,Mario Hlevnjak,Thorsten Kolb,Milena Simovic,Daniel Haag,Yashna Paul,Frauke Devens,Paul A. Northcott,Paul A. Northcott,David T. Jones,Marcel Kool,Anna Jauch,Agata Pastorczak,Wojciech Mlynarski,Andrey Korshunov,Rajesh Kumar,Susanna M. Downing,Stefan M. Pfister,Marc Zapatka,Peter J. McKinnon,Frederick W. Alt,Peter Lichter,Aurélie Ernst +24 more
TL;DR: The role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mouse models of medulloblastoma or high grade gliomas is analysed, pointing towards therapeutic opportunities to target DNA repair defects in tumors with complex genomic rearrangements.
Journal ArticleDOI
A versatile system to introduce clusters of genomic double‐strand breaks in large cell populations
Thorsten Kolb,Umar Khalid,Milena Simovic,Manasi Ratnaparkhe,John Wong,Anna Jauch,Peter Schmezer,Agata Rode,Shulamit Sebban,Daniel Haag,Michaela Hergt,Frauke Devens,Yosef Buganim,Marc Zapatka,Peter Lichter,Aurélie Ernst +15 more
TL;DR: The genome rearrangements in the irradiated cells were showed, providing a proof of principle for the induction of structural variants by localized DNA lesions by UV irradiation with photomasks.
Posted ContentDOI
Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures
Tobias Rausch,Rene Snajder,Adrien Leger,Milena Simovic,Oliver Stegle,Ewan Birney,Marc Jan Bonder,Aurélie Ernst,Jan O. Korbel +8 more
TL;DR: The study uncovers a complex SV pattern termed ‘templated insertion thread’, characterized by short (mostly <1kb) insertions showing prevalent self-concatenation into highly amplified structures of up to 50kbp in size, and shows the potential of long-read sequencing in cancer.
Journal ArticleDOI
IVM of mouse fully grown germinal vesicle oocytes upon a feeder layer of selected cumulus cells enhances their developmental competence.
Federica Cavalera,Milena Simovic,Mario Zanoni,Valeria Merico,Silvia Garagna,Maurizio Zuccotti +5 more
TL;DR: These results set a culture platform to further improve the protocols for the maturation of DOs and to unravel the molecules involved in the cross-talk between the gamete and its companion CCs during the germinal vesicle to MII transition.
Posted ContentDOI
A versatile system to introduce clusters of genomic double-strand breaks in large cell populations
Thorsten Kolb,Umar Khalid,Milena Simovic,Manasi Ratnaparkhe,John Wong,Anna Jauch,Peter Schmezer,Agata Rode,Shulamit Sebban,Daniel Haag,Michaela Hergt,Frauke Devens,Yosef Buganim,Marc Zapatka,Peter Lichter,Aurélie Ernst +15 more
TL;DR: A novel method generating localized DNA double-strand breaks using UV-irradiation with photomasks is presented, providing a proof of principle for the induction of structural variants by localized DNA lesions.