Milene Brownlow

TL;DR: The data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy, and Soluble Aβ1-42 oligomers have long-lasting effects on tau phosphorylation in the rTg4510 model.

TL;DR: The data suggest that ketogenic diets may play an important role in enhancing motor performance in mice, but have minimal impact on the phenotype of murine models of amyloid or tau deposition.

TL;DR: It is reported here that soluble fractalkine overexpression using adeno-associated viral vectors significantly reduced tau pathology in the rTg4510 mouse model of tau deposition, and agonism at fractalkin receptors might be an excellent target for therapeutic intervention in tauopathies, including those associated with amyloid deposition.

TL;DR: The data suggests that, despite an apparent rescue of associative memory, CR had no consistent effects on pathological outcomes of a mouse model of tau deposition.

TL;DR: While rAAV-IDE does not have the same therapeutic potential as rAAVs-NEP, rAAv-Nep-s and NEP-n are effective at reducing amyloid loads, and both of these vectors continue to have significant effects nine months post-injection, and may be considered reasonable candidates for gene therapy trials in AD.