M
Millard Jayne
Researcher at National Institutes of Health
Publications - 36
Citations - 6035
Millard Jayne is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Dopamine & Raclopride. The author has an hindex of 30, co-authored 36 publications receiving 5647 citations. Previous affiliations of Millard Jayne include Brookhaven National Laboratory.
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Journal ArticleDOI
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction.
Nora D. Volkow,Gene-Jack Wang,Frank Telang,Joanna S. Fowler,Jean Logan,Anna-Rose Childress,Millard Jayne,Yeming Ma,Christopher Wong +8 more
TL;DR: Evidence is provided that dopamine in the dorsal striatum is involved with craving and is a fundamental component of addiction, and strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction.
Journal ArticleDOI
"Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect.
Nora D. Volkow,Gene-Jack Wang,Joanna S. Fowler,Jean Logan,Millard Jayne,Dinko Franceschi,Cristopher Wong,Samuel J. Gatley,Andrew N. Gifford,Yu-Shin Ding,Naomi Pappas +10 more
TL;DR: The results provide the first evidence that dopamine in the dorsal striatum is involved in food motivation in humans that is distinct from its role in regulating reward through the NA, and the ability of methylphenidate to amplify weak dopamine signals is demonstrated.
Journal ArticleDOI
Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain: Clinical Implications
Nora D. Volkow,Joanna S. Fowler,Jean Logan,David Alexoff,Wei Zhu,Frank Telang,Gene-Jack Wang,Millard Jayne,Jacob M. Hooker,Christopher Wong,Barbara Hubbard,Pauline Carter,Donald Warner,Payton King,Colleen Shea,Youwen Xu,Lisa Muench,Karen Apelskog-Torres +17 more
TL;DR: In this pilot study, modafinil blocked dopamine transporters and increased dopamine in the human brain (including the nucleus accumbens), highlighting the need for heightened awareness for potential abuse of and dependence on modafInil in vulnerable populations.
Journal ArticleDOI
Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement
Nora D. Volkow,Gene-Jack Wang,Frank Telang,Joanna S. Fowler,Jean Logan,Millard Jayne,Yeming Ma,Kith Pradhan,Christopher Wong +8 more
TL;DR: Results are consistent with the hypothesis that the orbitofrontal cortex modulates the value of rewards by regulating the magnitude of dopamine increases in the ventral striatum and that disruption of this regulation may underlie the decreased sensitivity to rewards in addicted subjects.
Journal ArticleDOI
Exposure to appetitive food stimuli markedly activates the human brain
Gene-Jack Wang,Nora D. Volkow,Frank Telang,Millard Jayne,Jim Ma,Manlong Rao,Wei Zhu,Christopher Wong,N. Pappas,Allan Geliebter,Joanna S. Fowler +10 more
TL;DR: The activation of the right orbitofrontal cortex, a brain region involved with drive, may underlie the motivation to procure food, which may be subjectively experienced as "desire for food" and "hunger" when exposed to food stimuli.