M
Milos Grim
Researcher at Charles University in Prague
Publications - 87
Citations - 3091
Milos Grim is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Neural crest & Merkel cell. The author has an hindex of 27, co-authored 87 publications receiving 2972 citations. Previous affiliations of Milos Grim include University of Hamburg & University of Freiburg.
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Pluripotent neural crest stem cells in the adult hair follicle.
TL;DR: The data show that the adult mouse whisker follicle contains pluripotent neural crest stem cells, termed epidermal neural crest cells (eNCSC), which are promising candidates for diverse cell therapy paradigms because of their high degree of inherent plasticity and due to their easy accessibility in the skin.
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Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new results.
TL;DR: It is convinced that Merkel cells with associated nerve terminals function as mechanoreceptor cells, and the origin of a highly malignant skin cancer called Merkel cell carcinoma has been obtained.
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Melanoma cells influence the differentiation pattern of human epidermal keratinocytes
Ondřej Kodet,Lukáš Lacina,Lukáš Lacina,Eliska Krejci,Barbora Dvořánková,Milos Grim,Jiří Štork,Daniela Kodetova,Čestmír Vlček,Jana Šáchová,Michal Kolář,Hynek Strnad,Karel Smetana +12 more
TL;DR: It is concluded that the MC are able to influence locally the differentiation pattern of keratinocytes in vivo as well as in vitro, which highlights the role of intercellular interactions in melanoma.
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The Splotch mutation interferes with muscle development in the limbs
TL;DR: The specific disturbance of muscle development in the limbs of Splotch mutants thus suggests a role for Pax-3 in the organisation of the somite, the production of trophic factors in the limb mesenchyme or an alteration of myogenic and mesenchymal cells.
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The adult hair follicle: Cradle for pluripotent neural crest stem cells
Maya Sieber-Blum,Milos Grim +1 more
TL;DR: It is determined by in vitro clonal analysis that the bulge area of the adult whisker follicle contains pluripotent neural crest stem cells, termed epidermal neural creststem cells (eNCSCs), and one newly identified neural crest derivative, the Merkel cell.